Extended amygdala, conditioned withdrawal and memory consolidation.
Amygdala
/ physiopathology
Animals
Behavior, Addictive
/ physiopathology
Conditioning, Classical
/ drug effects
Cues
Drug-Seeking Behavior
Humans
Memory Consolidation
/ physiology
Neural Pathways
Nucleus Accumbens
/ physiopathology
Opioid-Related Disorders
/ physiopathology
Rats
Substance Withdrawal Syndrome
/ physiopathology
Conditioned withdrawal
Extended amygdala
Memory consolidation
Opioid addiction
Opioid withdrawal
Opioids
Journal
Progress in neuro-psychopharmacology & biological psychiatry
ISSN: 1878-4216
Titre abrégé: Prog Neuropsychopharmacol Biol Psychiatry
Pays: England
ID NLM: 8211617
Informations de publication
Date de publication:
08 03 2022
08 03 2022
Historique:
received:
18
05
2021
revised:
23
08
2021
accepted:
06
09
2021
pubmed:
13
9
2021
medline:
25
2
2022
entrez:
12
9
2021
Statut:
ppublish
Résumé
Opioid withdrawal can be associated to environmental cues through classical conditioning. Exposure to these cues can precipitate a state of conditioned withdrawal in abstinent subjects, and there are suggestions that conditioned withdrawal can perpetuate the addiction cycle in part by promoting the storage of memories. This review discusses evidence supporting the hypothesis that conditioned withdrawal facilitates memory consolidation by activating a neurocircuitry that involves the extended amygdala. Specifically, the central amygdala, the bed nucleus of the stria terminalis, and the nucleus accumbens shell interact functionally during withdrawal, mediate expression of conditioned responses, and are implicated in memory consolidation. From this perspective, the extended amygdala could be a neural pathway by which drug-seeking behaviour performed during a state of conditioned withdrawal is more likely to become habitual and persistent.
Identifiants
pubmed: 34509531
pii: S0278-5846(21)00194-9
doi: 10.1016/j.pnpbp.2021.110435
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110435Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.