Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya.

Adolescent Anti-Bacterial Agents / pharmacology Carrier State / microbiology Case-Control Studies Child Child, Preschool Drug Resistance, Multiple, Bacterial Female Humans Infant Kenya / epidemiology Male Phylogeny Salmonella typhi / classification Typhoid Fever / drug therapy
H58 lineages Kenya S. enterica serovar typhi carriage children epidemiology global health infectious disease microbiology multidrug-resistant typhoid

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
13 09 2021
Historique:
received: 24 02 2021
accepted: 08 09 2021
pubmed: 14 9 2021
medline: 23 11 2021
entrez: 13 9 2021
Statut: epublish

Résumé

Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control. In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya. 148 The high rate of multidrug-resistant H58 National Institutes of Health (R01AI099525); Wellcome Trust (106158/Z/14/Z); European Commission (TyphiNET No 845681); National Institute for Health Research (NIHR); Bill and Melinda Gates Foundation (OPP1175797).

Sections du résumé

Background
Understanding the dynamics of infection and carriage of typhoid in endemic settings is critical to finding solutions to prevention and control.
Methods
In a 3-year case-control study, we investigated typhoid among children aged <16 years (4670 febrile cases and 8549 age matched controls) living in an informal settlement, Nairobi, Kenya.
Results
148
Conclusions
The high rate of multidrug-resistant H58
Funding
National Institutes of Health (R01AI099525); Wellcome Trust (106158/Z/14/Z); European Commission (TyphiNET No 845681); National Institute for Health Research (NIHR); Bill and Melinda Gates Foundation (OPP1175797).

Identifiants

DOI: 10.7554/eLife.67852 PMID: 34515028 PMC: PMC8494480
pubmed: 34515028
doi: 10.7554/eLife.67852
pii: 67852
pmc: PMC8494480
doi:
pii:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI099525
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106158/Z/14/Z
Pays : United Kingdom

Informations de copyright

© 2021, Kariuki et al.

Déclaration de conflit d'intérêts

SK, ZD, CM, RN, SK, CW, SA, NG, RO, BO, SD, MA, JC, KH, GD No competing interests declared

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Auteurs

Samuel Kariuki (S)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.
Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.
ORCID: 0000-0003-3209-9503

Zoe A Dyson (ZA)

Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, United Kingdom.
Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
London School of Hygiene & Tropical Medicine, London, United Kingdom.
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.
ORCID: 0000-0002-8887-3492

Cecilia Mbae (C)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Ronald Ngetich (R)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Susan M Kavai (SM)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Celestine Wairimu (C)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Stephen Anyona (S)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Naomi Gitau (N)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Robert Sanaya Onsare (RS)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Beatrice Ongandi (B)

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Sebastian Duchene (S)

Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.

Mohamed Ali (M)

Department of International Health, John's Hopkins University, Baltimore, United States.

John David Clemens (JD)

International Diarrheal Diseases Research Centre, Dhaka, Bangladesh.

Kathryn E Holt (KE)

London School of Hygiene & Tropical Medicine, London, United Kingdom.
Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.

Gordon Dougan (G)

Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › État de porteur sain › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Régions géographiques › Afrique › Afrique subsaharienne › Afrique de l'Est › Kenya › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Salmonella › Salmonella enterica › Salmonella typhi › Multiple introductions of multidrug-resistant...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Salmonelloses › Fièvre typhoïde › Multiple introductions of multidrug-resistant...