Fusaric acid induces hepatic global m6A RNA methylation and differential expression of m6A regulatory genes
epitranscriptomics
fusaric acid
m6A RNA methylation
m6A erasers
m6A readers
m6A writers
mycotoxin
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
pubmed:
15
9
2021
medline:
29
6
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
N6-methyladenosine (m6A) is an abundant epitranscriptomic mark that regulates gene expression to execute cellular developmental programmes and environmental adaptation. Fusaric acid (FA) is a mycotoxin that contaminates agricultural foods and exerts toxicity in humans and animals; however, its epitranscriptomic effects are unclear. We investigated the effect of FA on global m6A RNA methylation and mRNA expression levels of key m6A regulatory genes in C57BL/6 mouse livers. C57BL/6 mice (
Identifiants
pubmed: 34517792
doi: 10.1080/15592294.2021.1975937
pmc: PMC9235881
doi:
Substances chimiques
RNA, Messenger
0
RNA
63231-63-0
Fusaric Acid
JWJ963070N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
695-703Références
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