Oxidative Phosphorylation Is a Metabolic Vulnerability in Chemotherapy-Resistant Triple-Negative Breast Cancer.
Anilides
/ pharmacology
Animals
Apoptosis
Cell Proliferation
Drug Resistance, Neoplasm
Drug Therapy, Combination
Female
Gene Expression Profiling
Genomics
Humans
Metabolome
Mice
Mice, Nude
Neoplasm Recurrence, Local
/ drug therapy
Oxadiazoles
/ pharmacology
Oxidative Phosphorylation
/ drug effects
Piperidines
/ pharmacology
Prognosis
Pyridines
/ pharmacology
Triple Negative Breast Neoplasms
/ drug therapy
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
29
09
2020
revised:
04
03
2021
accepted:
10
09
2021
pubmed:
15
9
2021
medline:
12
1
2022
entrez:
14
9
2021
Statut:
ppublish
Résumé
Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An
Identifiants
pubmed: 34518211
pii: 0008-5472.CAN-20-3242
doi: 10.1158/0008-5472.CAN-20-3242
pmc: PMC8563442
mid: NIHMS1741812
doi:
Substances chimiques
Anilides
0
IACS-010759
0
Oxadiazoles
0
Piperidines
0
Pyridines
0
cabozantinib
1C39JW444G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5572-5581Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009599
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA224065
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003167
Pays : United States
Informations de copyright
©2021 The Authors; Published by the American Association for Cancer Research.
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