New dimeric phloroglucinol derivatives from Agrimonia pilosa and their hepatoprotective activities.
Agrimonia pilosa
Dimeric phloroglucinols
Hepatoprotective activity
Rosaceae
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
12
07
2021
revised:
05
09
2021
accepted:
06
09
2021
pubmed:
16
9
2021
medline:
5
1
2022
entrez:
15
9
2021
Statut:
ppublish
Résumé
Five new dimeric phloroglucinol derivatives, agrimones A - E (1-5), were isolated from the whole plant of Agrimonia pilosa. Their structures including absolute configurations were determined by a series of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR), complemented with the comparison of the experimental and calculated ECD spectra, and gauge-independent atomic orbital (GIAO) NMR calculations. Notably, compounds 1 and 2 represent a highly oxidized 6/6/6 tricyclic ring skeleton based on the cis-fused paraquinone and chroman. Compounds 1a, 4, and 5 exhibited moderate hepatoprotective activities against APAP-induced HepG2 cell injury at 10 μM.
Identifiants
pubmed: 34525394
pii: S0045-2068(21)00718-5
doi: 10.1016/j.bioorg.2021.105341
pii:
doi:
Substances chimiques
Protective Agents
0
Acetaminophen
362O9ITL9D
Phloroglucinol
DHD7FFG6YS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105341Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.