Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.

Animals CD8-Positive T-Lymphocytes Carcinoma, Non-Small-Cell Lung Lung Neoplasms Mice Monoacylglycerol Lipases / genetics Monoglycerides Tumor Microenvironment
2-AG CD8+ T cells Endocannabinoid cannabinoid receptors immune cells lung cancer monoacylglycerol lipase

Journal

Oncoimmunology
ISSN: 2162-402X
Titre abrégé: Oncoimmunology
Pays: United States
ID NLM: 101570526

Informations de publication

Date de publication:
2021
Historique:
entrez: 16 9 2021
pubmed: 17 9 2021
medline: 16 10 2021
Statut: epublish

Résumé

Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis but the role of MGL in the tumor microenvironment (TME) is less known. Using a syngeneic tumor model with KP cells (Kras

Identifiants

DOI: 10.1080/2162402X.2021.1965319 PMID: 34527428 PMC: PMC8437460
pubmed: 34527428
doi: 10.1080/2162402X.2021.1965319
pii: 1965319
pmc: PMC8437460
doi:

Substances chimiques

Monoglycerides 0
Monoacylglycerol Lipases EC 3.1.1.23

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1965319

Subventions

Organisme : Austrian Science Fund FWF
ID : J 4547
Pays : Austria

Informations de copyright

© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

Déclaration de conflit d'intérêts

The author(s) report no conflict of interest.

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Auteurs

Melanie Kienzl (M)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
BioTechMed, Graz, Austria.

Carina Hasenoehrl (C)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Kathrin Maitz (K)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Arailym Sarsembayeva (A)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Ulrike Taschler (U)

Institute Of Molecular Biosciences, University Of Graz, Graz, Austria.

Paulina Valadez-Cosmes (P)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Oliver Kindler (O)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Dusica Ristic (D)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Sofia Raftopoulou (S)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Ana Santiso (A)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Thomas Bärnthaler (T)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.

Luka Brcic (L)

Diagnostic And Research Institute Of Pathology, Medical University Of Graz, Graz, Austria.

Lisa Hahnefeld (L)

Institute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.

Robert Gurke (R)

Institute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Fraunhofer Institute For Translational Medicine And Pharmacology ITMP, Frankfurt, Germany.

Dominique Thomas (D)

Institute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.

Gerd Geisslinger (G)

Institute Of Clinical Pharmacology, Goethe University, Frankfurt, Germany.
Fraunhofer Institute For Translational Medicine And Pharmacology ITMP, Frankfurt, Germany.

Julia Kargl (J)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
ORCID: 0000-0002-0870-0816

Rudolf Schicho (R)

Division Of Pharmacology, Otto Loewi Research Center, Medical University Of Graz, Graz, Austria.
BioTechMed, Graz, Austria.
ORCID: 0000-0002-5726-4731

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Acylglycerol lipase › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Lipides › Glycérides › Monoglycérides › Monoacylglycerol lipase deficiency in the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Monoacylglycerol lipase deficiency in the...