UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension.
diastolic function
hypertension
obesity
oxidative stress
uncoupling protein
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
21 09 2021
21 09 2021
Historique:
pubmed:
18
9
2021
medline:
5
2
2022
entrez:
17
9
2021
Statut:
ppublish
Résumé
Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3
Identifiants
pubmed: 34533037
doi: 10.1161/JAHA.121.022556
pmc: PMC8649532
doi:
Substances chimiques
Uncoupling Protein 3
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e022556Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL051971
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM104357
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136438
Pays : United States
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