The F11 Receptor (F11R)/Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A) in cancer progression.
Cancer progression
F11-receptor
F11R/JAM-A
JAM-A
Junctional Adhesion Molecule-A
Tight junction
Journal
Molecular and cellular biochemistry
ISSN: 1573-4919
Titre abrégé: Mol Cell Biochem
Pays: Netherlands
ID NLM: 0364456
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
05
02
2021
accepted:
08
09
2021
pubmed:
18
9
2021
medline:
15
3
2022
entrez:
17
9
2021
Statut:
ppublish
Résumé
The F11 Receptor (F11R), also called Junctional Adhesion Molecule-A (JAM-A) (F11R/JAM-A), is a transmembrane glycoprotein of the immunoglobulin superfamily, which is mainly located in epithelial and endothelial cell tight junctions and also expressed on circulating platelets and leukocytes. It participates in the regulation of various biological processes, as diverse as paracellular permeability, tight junction formation and maintenance, leukocyte transendothelial migration, epithelial-to-mesenchymal transition, angiogenesis, reovirus binding, and platelet activation. Dysregulation of F11R/JAM-A may result in pathological consequences and disorders in normal cell function. A growing body of evidence points to its role in carcinogenesis and invasiveness, but its tissue-specific pro- or anti-tumorigenic role remains a debated issue. The following review focuses on the F11R/JAM-A tissue-dependent manner in tumorigenesis and metastasis and also discusses the correlation between poor patient clinical outcomes and its aberrant expression. In the future, it will be required to clarify the signaling pathways that are activated or suppressed via the F11R/JAM-A protein in various cancer types to understand its multiple roles in cancer progression and further use it as a novel direct target for cancer treatment.
Identifiants
pubmed: 34533648
doi: 10.1007/s11010-021-04259-2
pii: 10.1007/s11010-021-04259-2
pmc: PMC8755661
doi:
Substances chimiques
Cell Adhesion Molecules
0
F11R protein, human
0
Neoplasm Proteins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-98Informations de copyright
© 2021. The Author(s).
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