The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.
COVID 19
convergent mutations
directional selection
diversifying selection
evolutionary adaptation
immune evasion
lineage-defining mutations
positive selection
recurrent mutations
transmission advantage
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
30 09 2021
30 09 2021
Historique:
received:
24
02
2021
revised:
05
07
2021
accepted:
01
09
2021
pubmed:
20
9
2021
medline:
14
10
2021
entrez:
19
9
2021
Statut:
ppublish
Résumé
The independent emergence late in 2020 of the B.1.1.7, B.1.351, and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three "501Y lineages" coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favored convergent mutations at 35 genome sites, mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition.
Identifiants
pubmed: 34537136
pii: S0092-8674(21)01050-3
doi: 10.1016/j.cell.2021.09.003
pmc: PMC8421097
pii:
doi:
Substances chimiques
Codon
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5189-5200.e7Subventions
Organisme : NHGRI NIH HHS
ID : U24 HG006941
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI135992
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134384
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12014/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19026
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19027
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U01 AI152151
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140970
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Commentaires et corrections
Type : UpdateOf
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests J.O.W. has been funded by Gilead Sciences, LLC (completed) and the CDC (ongoing) via grants and contracts to his institution unrelated to this research.
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