Innovative Drying Technologies for Biopharmaceuticals.

Biological Products Desiccation Freeze Drying Technology, Pharmaceutical
Biopharmaceuticals Characterization Techniques Drying Technologies Formulation Process Analytical Technology

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
20 Nov 2021
Historique:
received: 13 04 2021
revised: 24 08 2021
accepted: 15 09 2021
pubmed: 22 9 2021
medline: 10 11 2021
entrez: 21 9 2021
Statut: ppublish

Résumé

In the past two decades, biopharmaceuticals have been a breakthrough in improving the quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the growing demand of biopharmaceuticals, the need for reducing manufacturing costs is essential without compromising on the safety, quality, and efficacy of products. Batch Freeze-drying is the primary commercial means of manufacturing solid biopharmaceuticals. However, Freeze-drying is an economically unfriendly means of production with long production cycles, high energy consumption and heavy capital investment, resulting in high overall costs. This review compiles some potential, innovative drying technologies that have not gained popularity for manufacturing parenteral biopharmaceuticals. Some of these technologies such as Spin-freeze-drying, Spray-drying, Lynfinity® Technology etc. offer a paradigm shift towards continuous manufacturing, whereas PRINT® Technology and Microglassification

Identifiants

DOI: 10.1016/j.ijpharm.2021.121115 PMID: 34547393
pubmed: 34547393
pii: S0378-5173(21)00921-2
doi: 10.1016/j.ijpharm.2021.121115
pii:
doi:

Substances chimiques

Biological Products 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

121115

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Ashutosh Sharma (A)

Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Main Campus, Cork Road, Waterford X91K0EK, Ireland. Electronic address: ashutosh.sharma@postgrad.wit.ie.

Dikshitkumar Khamar (D)

Sanofi, Manufacturing Science, Analytics and Technology (MSAT), IDA Industrial Park, Waterford X91TP27, Ireland.

Sean Cullen (S)

Gilead Sciences, Commercial Manufacturing, IDA Business & Technology Park, Carrigtwohill, Co. Cork T45DP77, Ireland.

Ambrose Hayden (A)

Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Main Campus, Cork Road, Waterford X91K0EK, Ireland.

Helen Hughes (H)

Pharmaceutical and Molecular Biotechnology Research Centre (PMBRC), Waterford Institute of Technology, Main Campus, Cork Road, Waterford X91K0EK, Ireland.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Innovative Drying Technologies for Biopharmaceuticals.
questionsmedicales.fr › Phénomènes chimiques › Dessiccation › Innovative Drying Technologies for Biopharmaceuticals.
questionsmedicales.fr › Techniques d'investigation › Conservation biologique › Cryoconservation › Lyophilisation › Innovative Drying Technologies for Biopharmaceuticals.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Innovative Drying Technologies for Biopharmaceuticals.