IRON MAN interacts with BRUTUS to maintain iron homeostasis in
BTS
IMA
bHLH105
bHLH115
iron
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
accepted:
23
08
2021
entrez:
22
9
2021
pubmed:
23
9
2021
medline:
6
10
2021
Statut:
ppublish
Résumé
IRON MAN (IMA) peptides, a family of small peptides, control iron (Fe) transport in plants, but their roles in Fe signaling remain unclear. BRUTUS (BTS) is a potential Fe sensor that negatively regulates Fe homeostasis by promoting the ubiquitin-mediated degradation of bHLH105 and bHLH115, two positive regulators of the Fe deficiency response. Here, we show that IMA peptides interact with BTS. The C-terminal parts of IMA peptides contain a conserved BTS interaction domain (BID) that is responsible for their interaction with the C terminus of BTS.
Identifiants
pubmed: 34548401
pii: 2109063118
doi: 10.1073/pnas.2109063118
pmc: PMC8488653
pii:
doi:
Substances chimiques
Arabidopsis Proteins
0
Peptide Fragments
0
Transcription Factors
0
Iron
E1UOL152H7
BRUTUS protein, Arabidopsis
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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