Role of glypican-1 in regulating multiple cellular signaling pathways.
cancer
glypican-1
signaling pathways
therapeutic target
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
pubmed:
23
9
2021
medline:
9
11
2021
entrez:
22
9
2021
Statut:
ppublish
Résumé
Glypican-1 (GPC1) is one of the six glypican family members in humans. It is composed of a core protein with three heparan sulfate chains and attached to the cell membrane by a glycosyl-phosphatidylinositol anchor. GPC1 modulates various signaling pathways including fibroblast growth factors (FGF), vascular endothelial growth factor-A (VEGF-A), transforming growth factor-β (TGF-β), Wnt, Hedgehog (Hh), and bone morphogenic protein (BMP) through specific interactions with pathway ligands and receptors. The impact of these interactions on signaling pathways, activating or inhibitory, is dependent upon specific GPC1 domain interaction with pathway components, as well as cell surface context. In this review, we summarize the current understanding of the structure of GPC1, as well as its role in regulating multiple signaling pathways. We focus on the functions of GPC1 in cancer cells and how new insights into these signaling processes can inform its translational potential as a therapeutic target in cancer.
Identifiants
pubmed: 34550795
doi: 10.1152/ajpcell.00290.2021
pmc: PMC8616591
doi:
Substances chimiques
Antineoplastic Agents, Immunological
0
GPC1 protein, human
0
Glypicans
0
Immunoconjugates
0
Ligands
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
C846-C858Subventions
Organisme : Intramural NIH HHS
ID : Z01 BC010891
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA BC010891
Pays : United States
Références
Trends Cancer. 2018 Nov;4(11):741-754
pubmed: 30352677
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Cell Rep Med. 2021 Jul 21;2(7):100344
pubmed: 34337560
Clin Genet. 2005 Mar;67(3):193-208
pubmed: 15691355
PLoS One. 2018 Apr 19;13(4):e0196017
pubmed: 29672570
Elife. 2020 Mar 31;9:
pubmed: 32228854
Br J Cancer. 2020 Apr;122(9):1333-1341
pubmed: 32152502
Trends Pharmacol Sci. 2001 Apr;22(4):201-7
pubmed: 11282421
PLoS Pathog. 2009 Nov;5(11):e1000666
pubmed: 19936054
Front Oncol. 2019 Aug 02;9:708
pubmed: 31428581
Nat Rev Mol Cell Biol. 2013 Jul;14(7):416-29
pubmed: 23719536
Nat Neurosci. 2005 Mar;8(3):297-304
pubmed: 15746914
Nat Commun. 2017 Jan 19;8:14351
pubmed: 28102194
Nature. 2021 Aug;596(7873):590-596
pubmed: 34293799
Gastroenterology. 2020 Jun;158(8):2250-2265.e20
pubmed: 32060001
Hepatology. 2020 May;71(5):1696-1711
pubmed: 31520528
Nat Rev Cancer. 2017 May;17(5):318-332
pubmed: 28303906
Oncotarget. 2017 Apr 11;8(15):24741-24752
pubmed: 28445969
Dev Cell. 2008 May;14(5):700-11
pubmed: 18477453
Int J Cancer. 2018 Mar 1;142(5):1056-1066
pubmed: 29055044
J Clin Invest. 2008 Jan;118(1):89-99
pubmed: 18064304
Am J Med Genet A. 2010 Apr;152A(4):886-95
pubmed: 20358598
Cancer Med. 2017 Jun;6(6):1181-1191
pubmed: 28440066
J Biol Chem. 2002 Feb 1;277(5):3176-85
pubmed: 11700304
Nat Rev Cancer. 2011 May 26;11(7):493-501
pubmed: 21614026
Neuron. 2013 Aug 7;79(3):478-91
pubmed: 23931997
J Biol Chem. 2012 Apr 20;287(17):14040-51
pubmed: 22351761
Trends Cancer. 2017 Jan;3(1):56-71
pubmed: 28718426
Hepatology. 2019 Oct;70(4):1231-1245
pubmed: 30963603
Oncogene. 2000 Feb 21;19(8):1002-9
pubmed: 10713683
PLoS One. 2011;6(11):e27461
pubmed: 22096577
Asian J Surg. 2013 Jan;36(1):7-12
pubmed: 23270819
Hepatology. 2014 Aug;60(2):576-87
pubmed: 24492943
Bone. 2013 Aug;55(2):367-76
pubmed: 23624389
Cell. 2016 Feb 11;164(4):780-91
pubmed: 26830878
Eur J Cancer. 1995 Jul-Aug;31A(7-8):1061-4
pubmed: 7576992
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5869-74
pubmed: 20231458
MAbs. 2012 Sep-Oct;4(5):592-9
pubmed: 22820551
J Biol Chem. 2015 Sep 18;290(38):22991-3008
pubmed: 26203194
Cancer Rep. 2011;1(1):14-19
pubmed: 22563565
J Biol Chem. 2001 Nov 9;276(45):41921-9
pubmed: 11551944
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1083-91
pubmed: 23471984
Circ Res. 2010 Jun 25;106(12):1798-806
pubmed: 20576942
BMC Cancer. 2020 Dec 10;20(1):1214
pubmed: 33302918
J Clin Invest. 1998 Nov 1;102(9):1662-73
pubmed: 9802880
Front Oncol. 2019 Jul 12;9:614
pubmed: 31355137
Elife. 2018 Feb 06;7:
pubmed: 29405118
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6623-E6631
pubmed: 28739923
J Biol Chem. 2003 May 2;278(18):16045-53
pubmed: 12591930
Hepatology. 2011 Apr;53(4):1246-58
pubmed: 21480329
Oncotarget. 2017 Aug 24;8(60):101189-101202
pubmed: 29254156
J Neurochem. 2011 Mar;116(5):721-5
pubmed: 20681952
Nanomedicine. 2018 Oct;14(7):2365-2374
pubmed: 28648641
Nat Commun. 2015 Mar 11;6:6536
pubmed: 25758784
Clin Exp Pharmacol Physiol. 2010 Apr;37(4):417-21
pubmed: 19843094
Oncotarget. 2019 Feb 1;10(10):1045-1055
pubmed: 30800217
Nature. 2018 May;557(7706):495-496
pubmed: 29777190
EJNMMI Res. 2020 May 7;10(1):46
pubmed: 32382920
Dig Dis Sci. 2019 Jun;64(6):1493-1502
pubmed: 30730015
Dev Dyn. 1998 Jan;211(1):72-87
pubmed: 9438425
Neural Dev. 2009 Sep 04;4:33
pubmed: 19732411
Dev Biol. 2010 Dec 1;348(1):107-18
pubmed: 20883685
Biochim Biophys Acta. 2010 Apr;1805(2):181-208
pubmed: 20085802
Elife. 2020 May 20;9:
pubmed: 32432544
Cancer Res. 2001 Jul 15;61(14):5562-9
pubmed: 11454708
Cell Rep Med. 2021 Jun 01;2(6):100297
pubmed: 34195677
Science. 2003 Mar 28;299(5615):2039-45
pubmed: 12663920
Sci Rep. 2016 May 17;6:26245
pubmed: 27185050
Br J Cancer. 2016 Jun 28;115(1):66-75
pubmed: 27310703
J Histochem Cytochem. 2020 Dec;68(12):841-862
pubmed: 32623934
J Biol Chem. 1999 Apr 16;274(16):10816-22
pubmed: 10196157
Gastroenterology. 2013 May;144(5):1107-1115.e3
pubmed: 23336978
Oncogene. 2012 May 17;31(20):2535-44
pubmed: 21996748
Cold Spring Harb Perspect Biol. 2011 Jul 01;3(7):
pubmed: 21690215
Nature. 2015 Jul 9;523(7559):177-82
pubmed: 26106858
Curr Pharm Des. 2014;20(17):2934-47
pubmed: 23944366
BioDrugs. 2011 Oct 1;25(5):275-84
pubmed: 21942912
Eur J Neurosci. 2008 Sep;28(5):964-72
pubmed: 18717736
Photodiagnosis Photodyn Ther. 2020 Dec;32:102064
pubmed: 33069874
Cell Biophys. 1994;24-25:155-61
pubmed: 7736520
Nat Rev Cancer. 2010 Feb;10(2):116-29
pubmed: 20094046
J Cell Biol. 2011 Feb 21;192(4):691-704
pubmed: 21339334
Curr Protoc Protein Sci. 2018 Nov;94(1):e66
pubmed: 30091851
Nat Rev Genet. 2011 Jun;12(6):393-406
pubmed: 21502959
Exp Gerontol. 2019 Oct 15;126:110693
pubmed: 31430521
Cancer Res. 2007 Jan 1;67(1):75-84
pubmed: 17210685
Am J Pathol. 2006 Jun;168(6):2014-26
pubmed: 16723715
Cell Signal. 2019 Feb;54:115-121
pubmed: 30500378
Development. 2015 May 15;142(10):1767-76
pubmed: 25968312
Cancer Res. 2004 Apr 1;64(7):2418-23
pubmed: 15059894
Int J Cancer. 2003 Feb 10;103(4):455-65
pubmed: 12478660
Biochemistry. 2011 Nov 1;50(43):9377-87
pubmed: 21932778
Int J Oncol. 2006 Nov;29(5):1139-48
pubmed: 17016645
J Biol Chem. 2018 Jun 22;293(25):9759-9769
pubmed: 29752411
Eur J Neurosci. 2004 Mar;19(5):1119-32
pubmed: 15016071
J Cancer. 2016 May 21;7(8):1002-9
pubmed: 27313791