Relationship of APOE, age at onset, amyloid and clinical phenotype in Alzheimer disease.
Apolipoprotein
Atypical Alzheimer's disease
Beta-amyloid, PET
Logopenic
Posterior cortical atrophy
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
08
02
2021
revised:
13
08
2021
accepted:
18
08
2021
pubmed:
23
9
2021
medline:
27
1
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
The apolipoprotein E (APOE) ε4 allele is the most well-established risk factor for Alzheimer's disease (AD), although its relationship to age at onset and clinical phenotype is unclear. We aimed to assess relationships between APOE genotype and age at onset, amyloid-beta (Aβ) deposition and typical versus atypical clinical presentations in AD. Frequency of APOE ε4 carriers by age at onset was assessed in 447 AD patients, 138 atypical AD patients recruited by the Neurodegenerative Research Group at Mayo Clinic, and 309 with typical AD from ADNI. APOE ε4 frequency increased with age at onset in atypical AD but showed a bell-shaped curve in typical AD where highest frequencies were observed between 65 and 70 years. Typical AD showed higher APOE ε4 frequencies than atypical AD only between the ages of 57 and 69 years. Global Aβ standard uptake value ratios did not differ according to APOE e4 status in either group. APOE genotype varies by both age at onset and clinical phenotype in AD, highlighting the heterogeneous nature of AD.
Identifiants
pubmed: 34551374
pii: S0197-4580(21)00266-9
doi: 10.1016/j.neurobiolaging.2021.08.012
pmc: PMC8616794
mid: NIHMS1735676
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
90-98Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061796
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC010367
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG046139
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062677
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050603
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
Références
J Alzheimers Dis. 2018;64(4):1227-1233
pubmed: 30010126
Alzheimers Dement. 2015 Jul;11(7):757-71
pubmed: 26194311
JAMA. 1997 Oct 22-29;278(16):1349-56
pubmed: 9343467
Neurology. 2010 Jan 19;74(3):201-9
pubmed: 20042704
Alzheimers Dement (N Y). 2018 Oct 30;4:602-608
pubmed: 30450407
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Ann Neurol. 2013 Dec;74(6):826-36
pubmed: 23536396
Alzheimers Dement. 2017 Mar;13(3):205-216
pubmed: 27697430
Alzheimers Res Ther. 2018 Aug 7;10(1):77
pubmed: 30086796
Neurology. 2009 Apr 28;72(17):1487-94
pubmed: 19339712
JAMA Neurol. 2018 Nov 1;75(11):1347-1354
pubmed: 30422173
Alzheimers Dement. 2014 Nov;10(6):630-6
pubmed: 24985533
Ann Clin Transl Neurol. 2016 Aug 26;3(9):668-77
pubmed: 27648456
Nat Genet. 1998 Aug;19(4):321-2
pubmed: 9697689
Alzheimers Dement. 2017 Aug;13(8):870-884
pubmed: 28259709
Neurology. 2021 Feb 2;96(5):e650-e661
pubmed: 33262228
Am J Hum Genet. 1997 Feb;60(2):439-46
pubmed: 9012418
Arch Neurol. 2006 Jan;63(1):155-6
pubmed: 16401755
Neurobiol Aging. 2000 Sep-Oct;21(5):735-40
pubmed: 11016543
Neurobiol Aging. 2010 Aug;31(8):1275-83
pubmed: 20472326
Brain. 2019 Jun 1;142(6):1701-1722
pubmed: 31135048
Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6820-5
pubmed: 19346482
Neurology. 2014 Apr 22;82(16):1455-62
pubmed: 24670887
Neurobiol Aging. 2013 Jan;34(1):1-12
pubmed: 22633529
Ann Neurol. 2010 Jan;67(1):122-31
pubmed: 20186853
Brain. 2013 Mar;136(Pt 3):844-58
pubmed: 23358601
Ann Clin Transl Neurol. 2020 May;7(5):707-721
pubmed: 32293805
Neurology. 2018 Sep 18;91(12):e1182-e1195
pubmed: 30143564
Neurobiol Aging. 2016 Jan;37:38-44
pubmed: 26507310
Ann Neurol. 1995 Apr;37(4):512-8
pubmed: 7717688
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8098-102
pubmed: 8367470
J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):266-73
pubmed: 23965289
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Neurology. 2004 Oct 12;63(7):1168-74
pubmed: 15477533
Neurology. 2017 Sep 5;89(10):1028-1034
pubmed: 28794245
Neuroimage. 2013 Sep;78:474-80
pubmed: 23624169
Neurology. 2018 May 1;90(18):e1605-e1612
pubmed: 29592889
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1075-80
pubmed: 14732699
JAMA Neurol. 2015 May;72(5):511-9
pubmed: 25775353
Ann Neurol. 2010 Mar;67(3):308-16
pubmed: 20373342
Neurology. 2006 Aug 8;67(3):526-7
pubmed: 16894123
Neurology. 2013 Mar 5;80(10):890-6
pubmed: 23446680
Neurology. 2013 Jan 22;80(4):359-65
pubmed: 23255822
Dement Geriatr Cogn Disord. 2007;23(1):60-6
pubmed: 17108687
JAMA Neurol. 2020 Apr 1;77(4):470-479
pubmed: 31860000
Ann Neurol. 2021 Mar;89(3):520-533
pubmed: 33274526
Nat Genet. 1994 Jun;7(2):180-4
pubmed: 7920638
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Neurology. 2011 May 17;76(20):1720-5
pubmed: 21576687
Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):159-63
pubmed: 21346518
Neurology. 2004 Jun 8;62(11):2116-8
pubmed: 15184629
J Neurosci Methods. 1994 Aug;53(2):125-7
pubmed: 7823614
Neurology. 1997 Jul;49(1):51-5
pubmed: 9222169
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1977-81
pubmed: 8446617
Alzheimers Res Ther. 2020 Oct 31;12(1):140
pubmed: 33129364
Alzheimers Dement. 2019 May;15(5):675-685
pubmed: 30853465
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Lancet Neurol. 2012 Oct;11(10):868-77
pubmed: 22951070
Sci Transl Med. 2011 Jun 29;3(89):89ra57
pubmed: 21715678