Capecitabine Can Induce T Cell Apoptosis: A Potential Immunosuppressive Agent With Anti-Cancer Effect.
Animals
Antimetabolites, Antineoplastic
/ pharmacology
Apoptosis
/ drug effects
Capecitabine
/ pharmacology
Cell Line, Tumor
Cytokines
/ metabolism
Endoplasmic Reticulum Stress
/ drug effects
Humans
Immunosuppressive Agents
/ pharmacology
Lymphoma, T-Cell
/ drug therapy
Male
Mice, Inbred BALB C
Mitochondria
/ drug effects
Reactive Oxygen Species
/ metabolism
T-Lymphocytes
/ drug effects
Thymidine Phosphorylase
/ metabolism
T cell
apoptosis
capecitabine
immunosuppression
thymidylate phosphorylase
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
07
2021
accepted:
23
08
2021
entrez:
24
9
2021
pubmed:
25
9
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Capecitabine (CAP) is now widely used in the comprehensive treatment of digestive system tumors. Some clinical observations have shown that CAP may have immunosuppressive effects, but there is still a lack of clear experimental verification. In this study, different doses of CAP were administered to normal mice by gavage. Our results confirmed that CAP did not cause myelosuppression in bone marrow tissue; CAP selectively reduced the proportion of T cells and the concentration of related pro-inflammatory cytokines, while it increased the concentration of anti-inflammatory cytokines. Thymidylate phosphorylase (TP) is the key enzyme for the transformation of CAP
Identifiants
pubmed: 34557199
doi: 10.3389/fimmu.2021.737849
pmc: PMC8452994
doi:
Substances chimiques
Antimetabolites, Antineoplastic
0
Cytokines
0
Immunosuppressive Agents
0
Reactive Oxygen Species
0
Capecitabine
6804DJ8Z9U
Thymidine Phosphorylase
EC 2.4.2.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
737849Informations de copyright
Copyright © 2021 Zhang, Wang, Fan, Liu, Yoshida, Yang, Liu, Hou, Cao, Wang, Song, Li, Zhang, Wang, Li, Zheng and Shen.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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