Target highlights in CASP14: Analysis of models by structure providers.
CASP
X-ray crystallography
community-wide experiment
cryo-EM
protein structure prediction
Journal
Proteins
ISSN: 1097-0134
Titre abrégé: Proteins
Pays: United States
ID NLM: 8700181
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
13
09
2021
received:
08
05
2021
accepted:
16
09
2021
pubmed:
26
9
2021
medline:
26
2
2022
entrez:
25
9
2021
Statut:
ppublish
Résumé
The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relevant features of the target proteins and discuss how well these features were reproduced in the respective submitted predictions. The overall ability to predict three-dimensional structures of proteins has improved remarkably in CASP14, and many difficult targets were modeled with impressive accuracy. For the first time in the history of CASP, the experimentalists not only highlighted that computational models can accurately reproduce the most critical structural features observed in their targets, but also envisaged that models could serve as a guidance for further studies of biologically-relevant properties of proteins.
Identifiants
pubmed: 34561912
doi: 10.1002/prot.26247
pmc: PMC8616854
mid: NIHMS1743318
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1647-1672Subventions
Organisme : NIGMS NIH HHS
ID : P41 GM103311
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI020459
Pays : United States
Organisme : NIH HHS
ID : S10 OD021600
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM100482
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI102546
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117373
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117930
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : HHSN272201700060C
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM137021
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA220430
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103832
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM079429
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA092584
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI020459
Pays : United States
Informations de copyright
© 2021 The Authors. Proteins: Structure, Function, and Bioinformatics published by Wiley Periodicals LLC.
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