The Clinical Value of GDF15 and Its Prospective Mechanism in Sepsis.
Adult
Aged
Animals
Female
Growth Differentiation Factor 15
/ blood
Humans
Janus Kinase 1
/ physiology
Macrophages
/ immunology
Male
Mice
Middle Aged
Prognosis
RAW 264.7 Cells
STAT3 Transcription Factor
/ physiology
Sepsis
/ blood
Severity of Illness Index
Shock, Septic
/ diagnosis
Signal Transduction
THP-1 Cells
Transcription Factor RelA
/ metabolism
GDF15
JAK1/STAT3
NF-κB p65
biomarker
inflammation
macrophage polarization
phagocytosis and sterilization
sepsis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
05
2021
accepted:
17
08
2021
entrez:
27
9
2021
pubmed:
28
9
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Growth differentiation factor 15 (GDF15) is involved in the occurrence and development of many diseases, and there are few studies on its relationship with sepsis. This article aims to explore the clinical value of GDF15 in sepsis and to preliminarily explore its prospective regulatory effect on macrophage inflammation and its functions. We recruited 320 subjects (132 cases in sepsis group, 93 cases in nonsepsis group, and 95 cases in control group), then detected the serum GDF15 levels and laboratory indicators, and further investigated the correlation between GDF15 and laboratory indicators, and also analyzed the clinical value of GDF15 in sepsis diagnosis, severity assessment, and prognosis.
Identifiants
pubmed: 34566964
doi: 10.3389/fimmu.2021.710977
pmc: PMC8456026
doi:
Substances chimiques
GDF15 protein, human
0
Growth Differentiation Factor 15
0
STAT3 Transcription Factor
0
STAT3 protein, human
0
Transcription Factor RelA
0
JAK1 protein, human
EC 2.7.10.2
Janus Kinase 1
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
710977Informations de copyright
Copyright © 2021 Li, Tang, Chen, Hu, Cai and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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