Loss of Dihydroxyacid Dehydratase Induces Auxotrophy in Bacillus anthracis.
amino acid dependency
anthrax
auxotrophy
bacillus
isoleucine
nutrient acquisition
Journal
Journal of bacteriology
ISSN: 1098-5530
Titre abrégé: J Bacteriol
Pays: United States
ID NLM: 2985120R
Informations de publication
Date de publication:
19 11 2021
19 11 2021
Historique:
pubmed:
28
9
2021
medline:
21
12
2021
entrez:
27
9
2021
Statut:
ppublish
Résumé
Anthrax disease is caused by infection with the bacteria Bacillus anthracis which, if left untreated, can result in fatal bacteremia and toxemia. Current treatment for infection requires prolonged administration of antibiotics. Despite this, inhalational and gastrointestinal anthrax still result in lethal disease. By identifying key metabolic steps that B. anthracis uses to grow in host-like environments, new targets for antibacterial strategies can be identified. Here, we report that the
Identifiants
pubmed: 34570623
doi: 10.1128/JB.00415-21
pmc: PMC8604071
doi:
Substances chimiques
Blood Proteins
0
Culture Media
0
Hemoglobins
0
Hydro-Lyases
EC 4.2.1.-
dihydroxyacid dehydratase
EC 4.2.1.9
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0041521Subventions
Organisme : NIAID NIH HHS
ID : AI09465
Pays : United States
Organisme : NIAID NIH HHS
ID : AI146481
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI125778
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI146481
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI097167
Pays : United States
Organisme : NIAID NIH HHS
ID : AI125778
Pays : United States
Organisme : NIAID NIH HHS
ID : AI097167
Pays : United States
Organisme : NIAID NIH HHS
ID : F32 AI009465
Pays : United States
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