Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells.
Animals
Cell Differentiation
Cells, Cultured
Female
Gene Expression Regulation, Developmental
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Sequence Analysis, RNA
Single-Cell Analysis
Spermatogenesis
Spermatogonia
/ metabolism
Stem Cells
/ metabolism
Ubiquitin Thiolesterase
/ physiology
UCH-L1
germ cell differentiation
metabolic regulation
mitochondrial capacity
murine spermatogenesis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
received:
07
06
2021
revised:
18
08
2021
accepted:
25
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Spermatogonia are stem and progenitor cells responsible for maintaining mammalian spermatogenesis. Preserving the balance between self-renewal of spermatogonial stem cells (SSCs) and differentiation is critical for spermatogenesis and fertility. Ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) is highly expressed in spermatogonia of many species; however, its functional role has not been identified. Here, we aimed to understand the role of UCH-L1 in murine spermatogonia using a
Identifiants
pubmed: 34571914
pii: cells10092265
doi: 10.3390/cells10092265
pmc: PMC8465610
pii:
doi:
Substances chimiques
Ubiquitin Thiolesterase
EC 3.4.19.12
Uchl1 protein, mouse
EC 3.4.19.12
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01 OD016575
Pays : United States
Organisme : NIH HHS
ID : OD016575-12
Pays : United States
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 03767-2016
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