Actions and Roles of FSH in Germinative Cells.
Animals
Dimerization
Female
Fertility
Follicle Stimulating Hormone
/ metabolism
Follicle Stimulating Hormone, beta Subunit
/ metabolism
Germ Cells
/ metabolism
Gonadotropins
/ metabolism
Granulosa Cells
/ metabolism
Humans
Male
Mice
Ovary
/ embryology
Pituitary Gland
/ embryology
Rats
Receptors, FSH
/ metabolism
Reproduction
Sertoli Cells
/ metabolism
Sexual Maturation
Spermatogenesis
/ genetics
Spermatogonia
/ cytology
germ cell line
gonadotrophin
reproduction
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Sep 2021
18 Sep 2021
Historique:
received:
30
07
2021
revised:
13
09
2021
accepted:
14
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
20
11
2021
Statut:
epublish
Résumé
Follicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic-pituitary-gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, α and β. The FSH β-subunit (FSHβ) function starts upon coupling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH β-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented.
Identifiants
pubmed: 34576272
pii: ijms221810110
doi: 10.3390/ijms221810110
pmc: PMC8470522
pii:
doi:
Substances chimiques
Follicle Stimulating Hormone, beta Subunit
0
Gonadotropins
0
Receptors, FSH
0
Follicle Stimulating Hormone
9002-68-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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