Ipertrofan Revisited-The Proposal of the Complete Stereochemistry of Mepartricin A and B.
NMR
absolute configuration
aromatic polyene macrolides
gedamycin
ipertrofan
mepartricin
partricin
prostate
stereochemistry
vacidin
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
12 Sep 2021
12 Sep 2021
Historique:
received:
17
08
2021
revised:
09
09
2021
accepted:
09
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
1
12
2021
Statut:
epublish
Résumé
Being a methyl ester of partricin, the mepartricin complex is the active substance of a drug called Ipertrofan (Tricandil), which was proven to be useful in treatment of benign prostatic hyperplasia and chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Nevertheless, no direct structural evidence on the stereochemistry of its components has been presented to date. In this contribution, we have conducted detailed, NMR-driven stereochemical studies on mepartricins A and B, aided by molecular dynamics simulations. The absolute configuration of all the stereogenic centers of mepartricin A and B was defined as 3
Identifiants
pubmed: 34577003
pii: molecules26185533
doi: 10.3390/molecules26185533
pmc: PMC8467382
pii:
doi:
Substances chimiques
Polyenes
0
Urological Agents
0
partricin
11096-49-4
Mepartricin
11121-32-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2016/23/B/NZ7/01223
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