Inverse heavy enzyme isotope effects in methylthioadenosine nucleosidases.
MTAN
femtosecond protein dynamics
isotope-substituted protein
transition-path sampling
transition-state formation
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
accepted:
27
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Heavy enzyme isotope effects occur in proteins substituted with
Identifiants
pubmed: 34580228
pii: 2109118118
doi: 10.1073/pnas.2109118118
pmc: PMC8501826
pii:
doi:
Substances chimiques
Isotopes
0
Purine-Nucleoside Phosphorylase
EC 2.4.2.1
5'-methylthioadenosine phosphorylase
EC 2.4.2.28
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM068036
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM041916
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM041916
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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