A high-Z inorganic scintillator-based detector for time-resolved in vivo dosimetry during brachytherapy.
brachytherapy
dosimetry
in vivo dosimetry
inorganic scintillators
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
08
08
2021
received:
18
05
2021
accepted:
09
09
2021
pubmed:
30
9
2021
medline:
18
11
2021
entrez:
29
9
2021
Statut:
ppublish
Résumé
High-dose rate (HDR) and pulsed-dose rate (PDR) brachytherapy would benefit from an independent treatment verification system to monitor treatment delivery and to detect errors in real time. This paper characterizes and provides an uncertainty budget for a detector based on a fiber-coupled high-Z inorganic scintillator capable of performing time-resolved in vivo dosimetry during HDR and PDR brachytherapy. The detector was composed of a detector probe and an optical reader. The detector probe consisted of either a 0.5 × 0.4 × 0.4 mm The total uncertainty of the detector at a 20 mm probe-to-source distance was < 5.1% and < 5.8% for the HDR and PDR versions, respectively. Regarding the above characteristics, (1) the sensitivity of the detector decreased by an average of 1.4%/°C for detector probe temperatures varying from 22 to 37°C; (2) the energy dependence of the detector was nonlinear and depended on both probe-to-source distance and the angle between the probe and the brachytherapy source; (3) the median SNRs were 187 and 34 at a 20 mm probe-to-source distance for the HDR and PDR versions, respectively (corresponding median source activities of 4.8 and 0.56 Ci, respectively); (4) the detector response varied by 0.6% in 11 identical irradiations over 8 h; (5) the sensitivity of the four detector probes decreased systematically by 0-1.2%/100 Gy of dose delivered to the probes, and random fluctuations of 4.8% in the sensitivity were observed for the three probes used in PDR and 1.9% for the probe used in HDR; and (6) the detector response was linear with dose rate. ZnSe:O detectors can be used effectively for in vivo dosimetry and with high accuracy for HDR and PDR brachytherapy applications.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7382-7398Subventions
Organisme : Aarhus University
Organisme : Novo Nordisk Fonden
ID : NNF19OC0058756
Organisme : The Danish Cancer Society
ID : R191-A11526
Organisme : The Danish Comprehensive Cancer Center
Organisme : National Cancer Institute, US National Institutes of Health
ID : R01CA120198
Informations de copyright
© 2021 American Association of Physicists in Medicine.
Références
Tanderup K, Beddar S, Andersen CE, Kertzscher G, Cygler JE. In vivo dosimetry in brachytherapy. Med Phys. 2013;40(7):070902. https://doi.org/10.1118/1.4810943.
Kertzscher G, Andersen CE, Tanderup K. Adaptive error detection for HDR/PDR brachytherapy: guidance for decision making during real-time in vivo point dosimetry. Med Phys. 2014;41(5):052102. https://doi.org/10.1118/1.4870438.
Andersen CE, Nielsen SK, Lindegaard JC, Tanderup K. Time-resolved in vivo luminescence dosimetry for online error detection in pulsed dose-rate brachytherapy. Med Phys. 2009;36:5033. https://doi.org/10.1118/1.3238102.
Johansen JG, Rylander S, Buus S, et al. Time-resolved in vivo dosimetry for source tracking in brachytherapy. Brachytherapy. 2018;17(1):122-132. https://doi.org/10.1016/j.brachy.2017.08.009.
Jørgensen EB, Kertzscher G, Buus S, et al. Accuracy of an in vivo dosimetry-based source tracking method for afterloading brachytherapy-a phantom study. Med Phys. 2021;48(5):2614-2623 https://doi.org/10.1002/mp.14812.
Rosales HML, Johansen JG, Kertzscher G, Tanderup K, Beaulieu L, Beddar S. 3D source tracking and error detection in HDR using two independent scintillator dosimetry systems. Med Phys. 2020;48(5):2095-2107 https://doi.org/10.1002/mp.14607.
Rosales HML, Archambault L, Beddar S, Beaulieu L. Dosimetric performance of a multipoint plastic scintillator dosimeter as a tool for real-time source tracking in high dose rate Ir brachytherapy. Med Phys. 2020;47(9):4477-4490. https://doi.org/10.1002/mp.14246.
Johansen JG, Kertzscher G, Jørgensen EB, et al. Dwell time verification in brachytherapy based on time-resolved in vivo dosimetry. Phys Med. 2019;60:156-161. https://doi.org/10.1016/j.ejmp.2019.03.031.
Poder J, Howie A, Brown R, et al. Towards real time in-vivo rectal dosimetry during trans-rectal ultrasound based high dose rate prostate brachytherapy using MOSkin dosimeters. Radiother Oncol. 2020;151:273-279. https://doi.org/10.1016/j.radonc.2020.08.003.
Gambarini G, Carrara M, Tenconi C, et al. Online in vivo dosimetry in high dose rate prostate brachytherapy with MOSkin detectors: in phantom feasibility study. Appl Radiat Isot. 2014;83:222-226. https://doi.org/10.1016/j.apradiso.2013.06.001.
Guiral P, Ribouton J, Jalade P, et al. Design and testing of a phantom and instrumented gynecological applicator based on GaN dosimeter for use in high dose rate brachytherapy quality assurance. Med Phys. 2016;43(9):5240-5251. https://doi.org/10.1118/1.4961393.
Duan J, Macey DJ, Pareek PN, Brezovich IA. Real-time monitoring and verification of in vivo high dose rate brachytherapy using a pinhole camera. Med Phys. 2001;28(2):167-173. https://doi.org/10.1118/1.1339882.
Batič M, Burger J, Cindro V, et al. Verification of high dose rate 192Ir source position during brachytherapy treatment. Nucl Instrum Methods Phys Res A. 2010;617(1):206-208. https://doi.org/10.1016/j.nima.2009.09.122.
Watanabe Y, Muraishi H, Takei H, et al. Automated source tracking with a pinhole imaging system during high-dose-rate brachytherapy treatment. Phys Med Biol. 2018;63(14):145002. https://doi.org/10.1088/1361-6560/aacdc9.
Smith RL, Hanlon M, Panettieri V, et al. An integrated system for clinical treatment verification of HDR prostate brachytherapy combining source tracking with pretreatment imaging. Brachytherapy. 2018;17(1):111-121. https://doi.org/10.1016/j.brachy.2017.08.004.
Fonseca G, Podesta M, Reniers B, Verhaegen F. MO-AB-BRA-03: development of novel real time in vivo EPID treatment verification for brachytherapy. Med Phys. 2016;43(6Part28):3691-3691. https://doi.org/10.1118/1.4957155.
Rosales HML, Duguay-Drouin P, Archambault L, Beddar S, Beaulieu L. Optimization of a multipoint plastic scintillator dosimeter for high dose rate brachytherapy. Med Phys. 2019;46(5):2412-2421. https://doi.org/10.1002/mp.13498.
Therriault-Proulx F, Beddar S, Beaulieu L. On the use of a single-fiber multipoint plastic scintillation detector for 192Ir high-dose-rate brachytherapy. Med Phys. 2013;40(6):062101. https://doi.org/10.1118/1.4803510.
Andersen CE, Nielsen SK, Greilich S, Helt-Hansen J, Lindegaard JC, Tanderup K. Characterization of a fiber-coupled luminescence dosimetry system for online in vivo dose verification during brachytherapy. Med Phys. 2009;36(3):708-718. https://doi.org/10.1118/1.3063006.
Archambault L, Therriault-Proulx F, Beddar S, Beaulieu L. A mathematical formalism for hyperspectral, multipoint plastic scintillation detectors. Phys Med Biol. 2012;57(21):7133-7145. https://doi.org/10.1088/0031-9155/57/21/7133.
Beddar AS, Mackie TR, Attix FH. Cerenkov light generated in optical fibers and other light-pipes irradiated by electron beams. Phys Med Biol. 1992;37:925-935.
Kertzscher G, Andersen CE, Edmund JM, Tanderup K. Stem signal suppression in fiber-coupled Al2O3:c dosimetry for 192Ir brachytherapy. Radiat Meas. 2011;46(12):2020-2024. https://doi.org/10.1016/j.radmeas.2011.05.079.
Therriault-Proulx F, Beddar S, Briere TM, Archambault L, Beaulieu L. Technical note: removing the stem effect when performing Ir-192 HDR brachytherapy in vivo dosimetry using plastic scintillation detectors: a relevant and necessary step. Med Phys. 2011;38(4):2176-2179. https://doi.org/10.1118/1.3562902.
Kertzscher G, Beddar S. Inorganic scintillation detectors for 192Ir brachytherapy. Phys Med Biol. 2019;64(22):225018. https://doi.org/10.1088/1361-6560/ab421f.
Kaveckyte V, Malusek A, Benmakhlouf H, Alm Carlsson G, Carlsson Tedgren Å. Suitability of microDiamond detectors for the determination of absorbed dose to water around high-dose-rate 192 Ir brachytherapy sources. Med Phys. 2018;45(1):429-437. https://doi.org/10.1002/mp.12694.
Verhaegen F, Fonseca GP, Johansen JG, et al. Future directions of in vivo dosimetry for external beam radiotherapy and brachytherapy. Phys Imag Radiat Oncol. 2020;16:18-19. https://doi.org/10.1016/j.phro.2020.09.001.
Fonseca GP, Johansen JG, Smith RL, et al. In vivo dosimetry in brachytherapy: requirements and future directions for research, development, and clinical practice. Phys Imag Radiat Oncol. 2020;16:1-11. https://doi.org/10.1016/j.phro.2020.09.002.
Wootton L, Beddar S. Temperature dependence of BCF plastic scintillation detectors. Phys Med Biol. 2013;58(9):2955-2967. PMID: 23574889.
International Organization for Standardization. Evaluation of measurement data-guide to the expression of uncertainty in measurement. International Organization for Standardization, Switzerland; 2008.
Taylor REP, Rogers DWO. EGSnrc Monte Carlo calculated dosimetry parameters for 192Ir and 169Yb brachytherapy sources. Med Phys. 2008;35(11):4933-4944. https://doi.org/10.1118/1.2987676.
Rivard MJ, Coursey BM, DeWerd LA, et al. Update of AAPM Task Group No. 43 report: a revised AAPM protocol for brachytherapy dose calculations. Med Phys. 2004;31(3):633-674. https://doi.org/10.1118/1.1646040.
Mecademic. Industrial robotics in the palm of your hand. 2020. Accessed March 22, 2021. https://cdn.mecademic.com/uploads/docs/meca500-brochure.pdf
DeWerd LA, Ibbott GS, Meigooni AS, et al. A dosimetric uncertainty analysis for photon-emitting brachytherapy sources: report of AAPM Task Group No. 138 and GEC-ESTRO. Med Phys. 2011;38(2):782-801. https://doi.org/10.1118/1.3533720.
Perez-Calatayud J, Ballester F, Das RK, et al. Dose calculation for photon-emitting brachytherapy sources with average energy higher than 50 keV: report of the AAPM and ESTRO: high-energy photon-emitting brachytherapy dosimetry. Med Phys. 2012;39(5):2904-2929. https://doi.org/10.1118/1.3703892.
Kirisits C, Rivard MJ, Baltas D, et al. Review of clinical brachytherapy uncertainties: analysis guidelines of GEC-ESTRO and the AAPM. Radiother Oncol. 2014;110(1):199-212. https://doi.org/10.1016/j.radonc.2013.11.002.
Kertzscher G, Andersen CE, Siebert F-A, Nielsen SK, Lindegaard JC, Tanderup K. Identifying afterloading PDR and HDR brachytherapy errors using real-time fiber-coupled Al(2)O(3):c dosimetry and a novel statistical error decision criterion. Radiother Oncol. 2011;100(3):456-462. https://doi.org/10.1016/j.radonc.2011.09.009.
Beddar S. On possible temperature dependence of plastic scintillator response. Med Phys. 2012;39(10):6522-6522. https://doi.org/10.1118/1.4748508.
Andersen CM, Edmund J, Damkjaer S, Greilich S. Temperature coefficients for in vivo RL and OSL dosimetry using Al2O3:c. Radiat Meas. 2008;43(2-6):948-953. https://doi.org/10.1016/j.radmeas.2007.12.021.
Therriault-Proulx F, Wootton L, Beddar S. A method to correct for temperature dependence and measure simultaneously dose and temperature using a plastic scintillation detector. Phys Med Biol. 2015;60(20):7927-7939. https://doi.org/10.1088/0031-9155/60/20/7927.
Hamamatsu. Photodiode and preamp integrated with feedback resistance and capacitance. 2015. Accessed March 22, 2021. https://www.hamamatsu.com/resources/pdf/ssd/s8745-01_etc_kspd1065e.pdf
Measurement Computing. USB-2408 product data sheet. 2019. Accessed March 22, 2021. https://www.mccdaq.com/PDFs/specs/USB-2408-Series-data.pdf
Andersen CE, Damkjaer SMS, Kertzscher G, Greilich S, Aznar MC. Fiber-coupled radioluminescence dosimetry with saturated Al2O3:c crystals: characterization in 6 and 18 MV photon beams. Radiat Meas. 2011;46(10):1090-1098. https://doi.org/10.1016/j.radmeas.2011.06.063.