Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps: Relevance to Cystic Fibrosis.
CF
extracellular traps
histone H3
macrophage
neutrophil elastase
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
2
10
2021
medline:
19
2
2022
entrez:
1
10
2021
Statut:
ppublish
Résumé
Neutrophil extracellular traps increase cystic fibrosis (CF) airway inflammation. We hypothesized that macrophage exposure to neutrophil elastase (NE) would trigger the release of macrophage extracellular traps (METs), a novel mechanism to augment NE-induced airway inflammation in CF. Experiments were performed using human blood monocyte derived macrophages (hBMDM) from patients with and without CF to test specific mechanisms associated with MET release, and MET release by NE was confirmed in alveolar macrophages from
Identifiants
pubmed: 34597246
doi: 10.1165/rcmb.2020-0410OC
pmc: PMC8803356
doi:
Substances chimiques
Histones
0
DNA
9007-49-2
ELANE protein, human
EC 3.4.21.37
Leukocyte Elastase
EC 3.4.21.37
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-85Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL146811
Pays : United States
Organisme : CSR NIH HHS
ID : R01 HL146811-01A1
Pays : United States
Commentaires et corrections
Type : CommentIn
Références
J Cyst Fibros. 2010 Sep;9(5):314-22
pubmed: 20570573
J Leukoc Biol. 2015 Jun;97(6):1023-35
pubmed: 25877927
PLoS One. 2013 Sep 30;8(9):e75667
pubmed: 24098711
J Innate Immun. 2018;10(1):3-13
pubmed: 28988241
J Leukoc Biol. 2021 Mar;109(3):573-582
pubmed: 32678926
Am J Physiol Lung Cell Mol Physiol. 2004 Dec;287(6):L1293-302
pubmed: 15273079
Pediatr Pulmonol. 2015 Oct;50 Suppl 40:S39-56
pubmed: 26335954
Am J Physiol Lung Cell Mol Physiol. 2001 Sep;281(3):L556-64
pubmed: 11504681
Exp Lung Res. 2008 Nov;34(9):599-629
pubmed: 19005923
Antibiotics (Basel). 2015 Jan 15;4(1):62-75
pubmed: 27025615
Bioessays. 2015 Jan;37(1):70-9
pubmed: 25350939
Int J Biochem Cell Biol. 2008;40(6-7):1238-45
pubmed: 18395488
J Cell Biol. 2010 Nov 1;191(3):677-91
pubmed: 20974816
J Cyst Fibros. 2008 Jan;7(1):68-78
pubmed: 17889625
Blood. 2013 Oct 17;122(16):2784-94
pubmed: 24009232
J Leukoc Biol. 2017 Sep;102(3):775-781
pubmed: 28465447
Am J Respir Cell Mol Biol. 2014 Apr;50(4):684-9
pubmed: 24325600
Ann Rheum Dis. 2018 Dec;77(12):1790-1798
pubmed: 30120096
Am J Respir Crit Care Med. 2005 May 15;171(10):1070-6
pubmed: 15695494
Cancer Res. 2012 Jul 1;72(13):3153-62
pubmed: 22564522
Clin Transl Sci. 2009 Oct;2(5):333-9
pubmed: 20411049
J Biol Chem. 2017 Jun 16;292(24):10295-10305
pubmed: 28468826
Curr Mol Med. 2014;14(9):1164-72
pubmed: 25323999
Proc Natl Acad Sci U S A. 1982 Nov;79(22):6941-5
pubmed: 6960357
J Biol Chem. 2017 Jul 14;292(28):11970-11979
pubmed: 28588027
J Biol Chem. 2007 May 11;282(19):14645-54
pubmed: 17384412
Science. 2004 Mar 5;303(5663):1532-5
pubmed: 15001782
Eur Respir J. 2009 Sep;34(3):655-61
pubmed: 19386685
Sci Rep. 2017 Nov 30;7(1):16628
pubmed: 29192209
J Cyst Fibros. 2015 Jul;14(4):419-30
pubmed: 25814049
Am Rev Respir Dis. 1983 Apr;127(4):449-55
pubmed: 6551160
PLoS One. 2017 Oct 5;12(10):e0186169
pubmed: 28982193
Free Radic Biol Med. 2018 Dec;129:25-34
pubmed: 30189264
Int J Biochem Cell Biol. 2014 Jun;51:39-44
pubmed: 24685679
Am J Respir Cell Mol Biol. 2015 Nov;53(5):676-88
pubmed: 25870903
J Clin Invest. 1979 Sep;64(3):824-33
pubmed: 89120
Am J Respir Crit Care Med. 2015 Dec 15;192(12):1449-61
pubmed: 26331676
J Biol Chem. 2012 Oct 12;287(42):35341-35350
pubmed: 22915586
J Cyst Fibros. 2017 Jul;16(4):443-453
pubmed: 27856165
Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1;303(3):L181-8
pubmed: 22659878
J Innate Immun. 2016;8(6):550-563
pubmed: 27336915
J Leukoc Biol. 2012 Nov;92(5):1111-22
pubmed: 22859830
Am J Respir Cell Mol Biol. 2009 Mar;40(3):295-304
pubmed: 18776130
J Immunol. 2012 Dec 1;189(11):5476-84
pubmed: 23105141
BMB Rep. 2018 May;51(5):211-218
pubmed: 29540259
COPD. 2004 Apr;1(1):59-70
pubmed: 16997739
Am J Respir Cell Mol Biol. 2002 Apr;26(4):447-52
pubmed: 11919081