Systemic and intrathecal baclofen produce bladder antinociception in rats.
Antinociception
GABAB receptors
Interstitial cystitis/bladder pain syndrome
Urinary bladder
Journal
BMC urology
ISSN: 1471-2490
Titre abrégé: BMC Urol
Pays: England
ID NLM: 100968571
Informations de publication
Date de publication:
04 Oct 2021
04 Oct 2021
Historique:
received:
20
04
2021
accepted:
08
09
2021
entrez:
5
10
2021
pubmed:
6
10
2021
medline:
19
2
2022
Statut:
epublish
Résumé
Baclofen, a clinically available GABA A series of experiments examined the effects of systemic and spinally administered baclofen on bladder nociception in female anesthetized rats. Models of bladder nociception included those which employed neonatal and adult bladder inflammation to produce bladder hypersensitivity. Cumulative intraperitoneal dosing (1-8 mg/kg IP) and cumulative intrathecal dosing (10-160 ng IT) of baclofen led to dose-dependent inhibition of visceromotor responses (VMRs) to urinary bladder distension (UBD) in all tested models. There were no differences in the magnitude of the analgesic effects of baclofen as a function of inflammation versus no inflammation treatments. Hemodynamic (pressor) responses to UBD were similarly inhibited by IT baclofen as well as UBD-evoked excitatory responses of spinal dorsal horn neurons. The GABA These data provide support for a clinical trial of baclofen as a non-opioid treatment of human bladder pain.
Sections du résumé
BACKGROUND
BACKGROUND
Baclofen, a clinically available GABA
METHODS
METHODS
A series of experiments examined the effects of systemic and spinally administered baclofen on bladder nociception in female anesthetized rats. Models of bladder nociception included those which employed neonatal and adult bladder inflammation to produce bladder hypersensitivity.
RESULTS
RESULTS
Cumulative intraperitoneal dosing (1-8 mg/kg IP) and cumulative intrathecal dosing (10-160 ng IT) of baclofen led to dose-dependent inhibition of visceromotor responses (VMRs) to urinary bladder distension (UBD) in all tested models. There were no differences in the magnitude of the analgesic effects of baclofen as a function of inflammation versus no inflammation treatments. Hemodynamic (pressor) responses to UBD were similarly inhibited by IT baclofen as well as UBD-evoked excitatory responses of spinal dorsal horn neurons. The GABA
CONCLUSIONS
CONCLUSIONS
These data provide support for a clinical trial of baclofen as a non-opioid treatment of human bladder pain.
Identifiants
pubmed: 34607587
doi: 10.1186/s12894-021-00899-0
pii: 10.1186/s12894-021-00899-0
pmc: PMC8489106
doi:
Substances chimiques
GABA-B Receptor Agonists
0
Baclofen
H789N3FKE8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK051413
Pays : United States
Organisme : NIDDK NIH HHS
ID : DK51413
Pays : United States
Informations de copyright
© 2021. The Author(s).
Références
Jpn J Pharmacol. 1988 Jan;46(1):7-15
pubmed: 3367548
Methods Find Exp Clin Pharmacol. 1991 Dec;13(10):681-6
pubmed: 1663195
Eur J Phys Rehabil Med. 2012 Mar;48(1):39-45
pubmed: 21525824
J Urol. 2009 Jul;182(1):337-42
pubmed: 19447422
Life Sci. 1998;62(17-18):1525-30
pubmed: 9585130
J Urol. 2005 May;173(5):1805-11
pubmed: 15821592
Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):175-8
pubmed: 2414673
Neuromodulation. 2016 Aug;19(6):623-31
pubmed: 27433993
J Pharmacol Exp Ther. 1995 Oct;275(1):219-27
pubmed: 7562553
Psychopharmacology (Berl). 2004 Mar;172(2):179-86
pubmed: 14610636
Toxins (Basel). 2020 Feb 10;12(2):
pubmed: 32050685
ACS Chem Neurosci. 2020 Jun 17;11(12):1740-1755
pubmed: 32436697
Paraplegia. 1990 Sep;28(7):420-7
pubmed: 2250984
Nature. 2003 Jul 17;424(6946):316-20
pubmed: 12867983
Toxins (Basel). 2019 Oct 11;11(10):
pubmed: 31614473
BMC Psychiatry. 2003 Nov 18;3:16
pubmed: 14624703
Spinal Cord. 2010 Jun;48(6):483-6
pubmed: 19918253
J Pain Palliat Care Pharmacother. 2002;16(3):61-4
pubmed: 14640356
Pain Res Manag. 2019 Dec 12;2019:6091257
pubmed: 31915499
Curr Pain Headache Rep. 2020 May 6;24(6):27
pubmed: 32378039
J Neurophysiol. 1991 Jul;66(1):20-8
pubmed: 1919667
Am J Phys Med Rehabil. 1989 Jun;68(3):112-5
pubmed: 2730779
Br J Pharmacol. 1994 Dec;113(4):1561-6
pubmed: 7534191
Pediatr Neurol. 2014 Aug;51(2):252-4
pubmed: 25079574
Neuroscience. 1992;48(1):217-23
pubmed: 1316570
Stereotact Funct Neurosurg. 1995;65(1-4):101-5
pubmed: 8916336
Int J Prev Med. 2013 Feb;4(2):158-64
pubmed: 23542877
Jpn J Pharmacol. 1989 Jul;50(3):327-32
pubmed: 2761133
J Pain. 2010 Mar;11(3):247-55
pubmed: 19945355
J Pharmacol Exp Ther. 1995 Oct;275(1):274-84
pubmed: 7562560
Eur J Pharmacol. 2001 Jan 12;411(3):283-8
pubmed: 11164386
Naunyn Schmiedebergs Arch Pharmacol. 1987 Aug;336(2):197-203
pubmed: 2825042
J Urol. 2020 Dec;204(6):1275-1283
pubmed: 32628100
Neurourol Urodyn. 1993;12(2):163-70
pubmed: 7920673
Anaesth Intensive Care. 2009 Mar;37(2):319-20
pubmed: 19400501
BMC Urol. 2006 Feb 09;6:2
pubmed: 16469099
Psychopharmacology (Berl). 2007 May;192(1):79-85
pubmed: 17242923
J Pain. 2006 Jul;7(7):469-79
pubmed: 16814686
Methods Find Exp Clin Pharmacol. 1989 Oct;11(10):597-601
pubmed: 2511384
Eur J Neurol. 2019 Jun;26(6):831-849
pubmed: 30860637
Emerg Med Australas. 2006 Feb;18(1):77-82
pubmed: 16454779
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):277-82
pubmed: 12493843
J Pharmacol Exp Ther. 1991 Apr;257(1):360-8
pubmed: 1850472
Gen Pharmacol. 1988;19(1):87-9
pubmed: 3345902
Adv Pharmacol. 2010;58:373-96
pubmed: 20655489
J Urol. 2008 Mar;179(3):1178-83
pubmed: 18206170
Behav Neurosci. 2011 Apr;125(2):261-7
pubmed: 21463025
J Urol. 2002 Dec;168(6):2700-5
pubmed: 12442013
Synapse. 2003 Oct;50(1):1-6
pubmed: 12872287
Clin Ther. 1984;6(6):800-7
pubmed: 6391666
Eur J Pharmacol. 1984 Dec 15;107(1):91-4
pubmed: 6098483
Br J Pharmacol. 2014 Feb;171(4):995-1006
pubmed: 24224799
J Urol. 2010 Oct;184(4):1529-35
pubmed: 20723927
Pain Med. 2008 Jul-Aug;9(5):505-17
pubmed: 18777607
J Urol. 2007 Feb;177(2):450-6
pubmed: 17222607
Drug Alcohol Depend. 1984 Oct;14(2):101-11
pubmed: 6096107
BJU Int. 2007 Sep;100(3):588-92
pubmed: 17511770
Drugs. 2003;63(23):2595-611
pubmed: 14636079
Drug Alcohol Depend. 2011 Sep 1;117(2-3):176-83
pubmed: 21333466
J Urol. 1992 Dec;148(6):1849-55
pubmed: 1433619
Br J Urol. 1979 Dec;51(6):504-5
pubmed: 394795
Neuroscience. 2012 Jun 28;213:154-60
pubmed: 22525135
MMWR Recomm Rep. 2016 Mar 18;65(1):1-49
pubmed: 26987082
Behav Brain Res. 2009 Jan 3;196(1):11-4
pubmed: 18634832
Neurosci Lett. 2000 Oct 6;292(2):83-6
pubmed: 10998554
Pain Manag. 2012 Nov;2(6):603-8
pubmed: 24645891
Investig Clin Urol. 2017 Mar;58(2):134-139
pubmed: 28261683
J Urol. 2001 Mar;165(3):968-74
pubmed: 11176524
Neuropsychopharmacology. 2003 Mar;28(3):510-8
pubmed: 12629530
J Urol. 1997 Jun;157(6):2361-5
pubmed: 9146671
Neuroscience. 2011 Oct 13;193:411-20
pubmed: 21807068
Indian J Physiol Pharmacol. 1993 Jul;37(3):189-93
pubmed: 8276493
Jpn J Pharmacol. 1992 Oct;60(2):105-10
pubmed: 1336079
Eur J Pharmacol. 2005 May 9;514(2-3):159-64
pubmed: 15910802
Biull Eksp Biol Med. 1988 May;105(5):556-8
pubmed: 2838104
Brain Res. 2001 Dec 27;923(1-2):147-56
pubmed: 11743982
J Pain. 2007 Dec;8(12):914-23
pubmed: 17704007
Behav Brain Res. 2010 Mar 5;207(2):353-9
pubmed: 19840820
Neurourol Urodyn. 2009;28(5):442-6
pubmed: 19030181
Neuroscience. 1995 Nov;69(2):345-9
pubmed: 8552232
Pharmacol Biochem Behav. 2019 May;180:11-21
pubmed: 30851293
Clin Exp Obstet Gynecol. 2012;39(2):171-4
pubmed: 22905457
J Urol. 1980 Jul;124(1):82-4
pubmed: 7411729
J Physiol. 2007 Jan 15;578(Pt 2):439-50
pubmed: 17068103
Pain. 2009 Jun;143(3):228-232
pubmed: 19375225
Neuropharmacology. 2007 Jun;52(7):1555-62
pubmed: 17451755
Spinal Cord. 2009 Oct;47(10):751-6
pubmed: 19333246
Eur J Neurosci. 2013 Feb;37(3):417-28
pubmed: 23136905
J Urol. 1993 Aug;150(2 Pt 1):537-42
pubmed: 8392118
J Urol. 1989 Jan;141(1):143-7
pubmed: 2908942
Gen Pharmacol. 1988;19(5):703-6
pubmed: 3215482
Neurocrit Care. 2011 Feb;14(1):103-8
pubmed: 20717751
Br J Anaesth. 1985 Oct;57(10):954-5
pubmed: 4041321
Acta Neurochir Suppl. 1995;64:17-25
pubmed: 8748577
Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1230-8
pubmed: 11003988
Neurourol Urodyn. 2008;27(3):249-53
pubmed: 17598175
J Urol. 1989 Jul;142(1):101-5
pubmed: 2733083
Neurourol Urodyn. 2020 Jun;39(5):1313-1320
pubmed: 32330365
Int J Environ Res Public Health. 2020 Apr 26;17(9):
pubmed: 32357440