Overlapping genes in natural and engineered genomes.
Journal
Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
accepted:
26
08
2021
pubmed:
7
10
2021
medline:
26
2
2022
entrez:
6
10
2021
Statut:
ppublish
Résumé
Modern genome-scale methods that identify new genes, such as proteogenomics and ribosome profiling, have revealed, to the surprise of many, that overlap in genes, open reading frames and even coding sequences is widespread and functionally integrated into prokaryotic, eukaryotic and viral genomes. In parallel, the constraints that overlapping regions place on genome sequences and their evolution can be harnessed in bioengineering to build more robust synthetic strains and constructs. With a focus on overlapping protein-coding and RNA-coding genes, this Review examines their discovery, topology and biogenesis in the context of their genome biology. We highlight exciting new uses for sequence overlap to control translation, compress synthetic genetic constructs, and protect against mutation.
Identifiants
pubmed: 34611352
doi: 10.1038/s41576-021-00417-w
pii: 10.1038/s41576-021-00417-w
pmc: PMC8490965
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
154-168Informations de copyright
© 2021. Springer Nature Limited.
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