Staphylococcal phages and pathogenicity islands drive plasmid evolution.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
06 10 2021
06 10 2021
Historique:
received:
17
04
2021
accepted:
07
09
2021
entrez:
7
10
2021
pubmed:
8
10
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Conjugation has classically been considered the main mechanism driving plasmid transfer in nature. Yet bacteria frequently carry so-called non-transmissible plasmids, raising questions about how these plasmids spread. Interestingly, the size of many mobilisable and non-transmissible plasmids coincides with the average size of phages (~40 kb) or that of a family of pathogenicity islands, the phage-inducible chromosomal islands (PICIs, ~11 kb). Here, we show that phages and PICIs from Staphylococcus aureus can mediate intra- and inter-species plasmid transfer via generalised transduction, potentially contributing to non-transmissible plasmid spread in nature. Further, staphylococcal PICIs enhance plasmid packaging efficiency, and phages and PICIs exert selective pressures on plasmids via the physical capacity of their capsids, explaining the bimodal size distribution observed for non-conjugative plasmids. Our results highlight that transducing agents (phages, PICIs) have important roles in bacterial plasmid evolution and, potentially, in antimicrobial resistance transmission.
Identifiants
pubmed: 34615859
doi: 10.1038/s41467-021-26101-5
pii: 10.1038/s41467-021-26101-5
pmc: PMC8494744
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5845Subventions
Organisme : Medical Research Council
ID : MR/M003876/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/V002376/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00940X/2
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N002873/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 201531/Z/16/Z
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S003835/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00940X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V000772/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
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