Peptides for T cell selection in the thymus.
T cell
Thymic cortex
Thymic medulla
Thymic selection
Thymoproteasome
Thymus
Journal
Peptides
ISSN: 1873-5169
Titre abrégé: Peptides
Pays: United States
ID NLM: 8008690
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
09
09
2021
revised:
29
09
2021
accepted:
30
09
2021
pubmed:
9
10
2021
medline:
24
3
2022
entrez:
8
10
2021
Statut:
ppublish
Résumé
Major histocompatibility complex (MHC)-associated peptides generated and displayed by antigen-presenting cells in the thymus are essential for the generation of functional and self-tolerant T cells that protect our body from various pathogens. The peptides displayed by cortical thymic epithelial cells (cTECs) are generated by unique enzymatic machineries including the thymoproteasomes, and are involved in the positive selection of self-protective T cells. On the other hand, the peptides displayed by medullary thymic epithelial cells (mTECs) and thymic dendritic cells (DCs) are involved in further selection to establish self-tolerance in T cells. Although the biochemical nature of the peptide repertoire displayed in the thymus remains unclear, many studies have suggested a thymus-specific mechanism for the generation of MHC-associated peptides in the thymus. In this review, we summarize basic knowledge and recent advances in MHC-associated thymic peptides, focusing on the generation and function of thymoproteasome-dependent peptides specifically displayed by cTECs.
Identifiants
pubmed: 34624431
pii: S0196-9781(21)00179-0
doi: 10.1016/j.peptides.2021.170671
pmc: PMC9309017
mid: NIHMS1819985
pii:
doi:
Substances chimiques
Histocompatibility Antigens Class I
0
Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
170671Subventions
Organisme : Intramural NIH HHS
ID : ZIA BC011806
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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