Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV).
Aniline Compounds
/ chemical synthesis
Antiviral Agents
/ chemical synthesis
Dengue Virus
/ drug effects
Dose-Response Relationship, Drug
Encephalitis Virus, Venezuelan Equine
/ drug effects
Microbial Sensitivity Tests
Molecular Structure
Quinazolines
/ chemical synthesis
Structure-Activity Relationship
Alphavirus
Antiviral
Dengue virus
Flavivirus
Venezuelan equine encephalitis virus
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 11 2021
15 11 2021
Historique:
received:
12
08
2021
revised:
22
09
2021
accepted:
01
10
2021
pubmed:
9
10
2021
medline:
8
1
2022
entrez:
8
10
2021
Statut:
ppublish
Résumé
There is an urgent need for novel strategies for the treatment of emerging arthropod-borne viral infections, including those caused by dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV). We prepared and screened focused libraries of 4-anilinoquinolines and 4-anilinoquinazolines for antiviral activity and identified three potent compounds. N-(2,5-dimethoxyphenyl)-6-(trifluoromethyl)quinolin-4-amine (10) inhibited DENV infection with an EC
Identifiants
pubmed: 34624490
pii: S0960-894X(21)00634-X
doi: 10.1016/j.bmcl.2021.128407
pii:
doi:
Substances chimiques
Aniline Compounds
0
Antiviral Agents
0
Quinazolines
0
anilinoquinazoline
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
128407Subventions
Organisme : Wellcome Trust
ID : 106169/ZZ14/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.