Collective effects in epithelial cell death and cell extrusion.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
07
06
2021
revised:
06
09
2021
accepted:
14
09
2021
pubmed:
10
10
2021
medline:
5
4
2022
entrez:
9
10
2021
Statut:
ppublish
Résumé
Programmed cell death, notably apoptosis, is an essential guardian of tissue homeostasis and an active contributor of organ shaping. While the regulation of apoptosis has been mostly analysed in the framework of a cell autonomous process, recent works highlighted important collective effects which can tune cell elimination. This is particularly relevant for epithelial cell death, which requires fine coordination with the neighbours in order to maintain tissue sealing during cell expulsion. In this review, we will focus on the recent advances which outline the complex multicellular communications at play during epithelial cell death and cell extrusion. We will first focus on the new unanticipated functions of neighbouring cells during extrusion, discuss the contribution of distant neighbours, and finally highlight the complex feedbacks generated by cell elimination on neighbouring cell death.
Identifiants
pubmed: 34626896
pii: S0959-437X(21)00110-6
doi: 10.1016/j.gde.2021.09.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8-14Informations de copyright
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