Lipotoxicity: a driver of heart failure with preserved ejection fraction?
diastolic dysfunction
heart failure with preserved ejection fraction
lipid metabolism
lipotoxicity
metabolic syndrome
Journal
Clinical science (London, England : 1979)
ISSN: 1470-8736
Titre abrégé: Clin Sci (Lond)
Pays: England
ID NLM: 7905731
Informations de publication
Date de publication:
15 10 2021
15 10 2021
Historique:
received:
17
05
2021
revised:
28
09
2021
accepted:
29
09
2021
entrez:
13
10
2021
pubmed:
14
10
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Heart failure with preserved ejection fraction (HFpEF) is a growing public health concern, with rising incidence alongside high morbidity and mortality. However, the pathophysiology of HFpEF is not yet fully understood. The association between HFpEF and the metabolic syndrome (MetS) suggests that dysregulated lipid metabolism could drive diastolic dysfunction and subsequent HFpEF. Herein we summarise recent advances regarding the pathogenesis of HFpEF in the context of MetS, with a focus on impaired lipid handling, myocardial lipid accumulation and subsequent lipotoxicity.
Identifiants
pubmed: 34643676
pii: 229933
doi: 10.1042/CS20210127
pmc: PMC8543140
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2265-2283Subventions
Organisme : British Heart Foundation
ID : FS/17/61/33473
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/12/13/29853
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802051
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400192
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/5
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/7/33636
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12012/2
Pays : United Kingdom
Informations de copyright
© 2021 The Author(s).
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