Two triterpenoids from Rubus fraxinifolius leaves and their tyrosinase and elastase inhibitory activities.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 10 2021
14 10 2021
Historique:
received:
05
02
2021
accepted:
01
10
2021
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Numerous therapeutic compounds have been isolated from naturally abundant organic resources, which may offer economical and sustainable sources of compounds with safe and efficacious biological activities. In the cosmetics industry, natural compounds with anti-aging activities are eagerly sought. Thus, we prepared various extracts from Rubus fraxinifolius leaves and used enzyme inhibition assays to isolate compounds with protective effects against skin aging. Two triterpenoids were isolated from Rubus fraxinifolius Poir. leaves. The structures were characterized by spectroscopic analyses (LC-ESI-MS, 1D/2D NMR) and comparison to reported data. Compound 1 and 2 were determined as 2,3-O-ethyleneglycol, 19-hydroxyurs-12-en-23,28-dioic acid and 2,3-O-propanediol,19-hydroxyurs-12-en-28-oic acid. Methanol extract and isolates were assessed for their inhibitory effects on elastase and tyrosinase. Compounds 1 and 2 inhibited elastase with IC
Identifiants
pubmed: 34650166
doi: 10.1038/s41598-021-99970-x
pii: 10.1038/s41598-021-99970-x
pmc: PMC8516952
doi:
Substances chimiques
Triterpenes
0
Monophenol Monooxygenase
EC 1.14.18.1
Pancreatic Elastase
EC 3.4.21.36
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20452Informations de copyright
© 2021. The Author(s).
Références
Biochemistry. 2011 Jun 21;50(24):5477-86
pubmed: 21598903
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Int J Cosmet Sci. 2001 Dec;23(6):341-6
pubmed: 18498484
Biol Pharm Bull. 2007 May;30(5):999-1002
pubmed: 17473451
Molecules. 2017 Jan 17;22(1):
pubmed: 28106755
J Asian Nat Prod Res. 2020 Feb;22(2):131-137
pubmed: 30526062
Int J Mol Sci. 2016 Feb 18;17(2):160
pubmed: 26901191
Sci Rep. 2021 Feb 4;11(1):3198
pubmed: 33542326
Int J Mol Sci. 2015 Apr 08;16(4):7776-95
pubmed: 25856676
Evid Based Complement Alternat Med. 2015;2015:341216
pubmed: 26788108
Nat Prod Res. 2016;30(8):904-11
pubmed: 26305695
BMC Complement Altern Med. 2009 Aug 04;9:27
pubmed: 19653897
Pharm Biol. 2013 Sep;51(9):1182-7
pubmed: 23763301
PLoS One. 2013 Dec 20;8(12):e82794
pubmed: 24376583
Molecules. 2015 Sep 14;20(9):16723-40
pubmed: 26389869
J Chem Inf Model. 2020 Feb 24;60(2):667-683
pubmed: 31922754
Front Pharmacol. 2019 Jul 16;10:799
pubmed: 31379574
Inflammation. 2016 Jun;39(3):1151-9
pubmed: 27102898
Evid Based Complement Alternat Med. 2016;2016:2482930
pubmed: 27437023
Phytochemistry. 2015 Aug;116:329-336
pubmed: 25944373
Pharm Biol. 2016 Sep;54(9):1865-72
pubmed: 26912420
Int J Biol Macromol. 2018 Nov;119:470-476
pubmed: 30055279