Changes of omentin-1 and chemerin during 4 weeks of lifestyle intervention and 1 year follow-up in children with obesity.
Adolescent
Anthropometry
Behavior Therapy
/ methods
Body Mass Index
Cardiometabolic Risk Factors
Chemokines
/ blood
Child
Cytokines
/ blood
Female
Follow-Up Studies
GPI-Linked Proteins
/ blood
Humans
Lectins
/ blood
Life Style
Male
Obesity Management
/ methods
Pediatric Obesity
/ blood
Randomized Controlled Trials as Topic
Risk Reduction Behavior
Treatment Outcome
Weight Loss
Adolescence
Childhood
Exercise
Lifestyle intervention
Nutrition
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
21
04
2021
revised:
28
09
2021
accepted:
28
09
2021
pubmed:
20
10
2021
medline:
27
1
2022
entrez:
19
10
2021
Statut:
ppublish
Résumé
Data about the influence of short-term lifestyle intervention in children with obesity on long-term follow-up body weight, adipokines and cardiometabolic risk parameters is scarce. In a subgroup of the LOGIC-trial (Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children), we assessed anthropometry (BMI, BMI-SDS (Standard Deviation Score), adipokines (omentin-1, chemerin, leptin, adiponectin) and cardiometabolic risk parameters, (e.g. hsCRP) in children with overweight/obesity after 4 weeks of lifestyle intervention (n = 156, 14.0 ± 1.8 yrs) and after one year follow-up (n = 50). Data were compared to normal weight children (JuvenTUM school cohort; n = 152, 13.3 ± 0.7 yrs). Short-term lifestyle intervention was associated with a significant reduction in BMI and BMI-SDS (p < 0.001), with significant reductions in hsCRP, leptin, and chemerin levels, and an increase in adiponectin and omentin-1 levels (p < 0.001 for all). After one year follow-up a significant reduction in BMI and BMI-SDS was observed in children from the LOGIC-trial (p < 0.001). Improvements in adiponectin (p = 0.025) and chemerin levels (p = 0.027) were seen in children with clear weight loss success (BMI-SDS reduction ≥ 0.2), whereas children with no or only mild weight loss success showed an increase in leptin levels (p < 0.001). An increase in omentin-1 levels was observed after 1 year independent of weight change (p < 0.001). Effects of short-term weight reduction on mean BMI and BMI-SDS persist over one year. Improvements in omentin-1 levels were independent of short-term or long-term weight loss. ClinicalTrials.gov: LOGIC-trial: NCT01067157, JuvenTUM-trial: NCT00988754.
Identifiants
pubmed: 34666255
pii: S0261-5614(21)00466-0
doi: 10.1016/j.clnu.2021.09.042
pii:
doi:
Substances chimiques
Chemokines
0
Cytokines
0
GPI-Linked Proteins
0
ITLN1 protein, human
0
Lectins
0
RARRES2 protein, human
0
Banques de données
ClinicalTrials.gov
['NCT00988754', 'NCT01067157']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5648-5654Informations de copyright
Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors declare no conflicts of interest.