Heritability and genetic correlations of plasma metabolites of pigs with production, resilience and carcass traits under natural polymicrobial disease challenge.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
received:
25
06
2021
accepted:
23
09
2021
entrez:
20
10
2021
pubmed:
21
10
2021
medline:
9
2
2022
Statut:
epublish
Résumé
Metabolites in plasma of healthy nursery pigs were quantified using nuclear magnetic resonance. Heritabilities of metabolite concentration were estimated along with their phenotypic and genetic correlations with performance, resilience, and carcass traits in growing pigs exposed to a natural polymicrobial disease challenge. Variance components were estimated by GBLUP. Heritability estimates were low to moderate (0.11 ± 0.08 to 0.19 ± 0.08) for 14 metabolites, moderate to high (0.22 ± 0.09 to 0.39 ± 0.08) for 17 metabolites, and highest for L-glutamic acid (0.41 ± 0.09) and hypoxanthine (0.42 ± 0.08). Phenotypic correlation estimates of plasma metabolites with performance and carcass traits were generally very low. Significant genetic correlation estimates with performance and carcass traits were found for several measures of growth and feed intake. Interestingly the plasma concentration of oxoglutarate was genetically negatively correlated with treatments received across the challenge nursery and finisher (- 0.49 ± 0.28; P < 0.05) and creatinine was positively correlated with mortality in the challenge nursery (0.85 ± 0.76; P < 0.05). These results suggest that some plasma metabolite phenotypes collected from healthy nursery pigs are moderately heritable and genetic correlations with measures of performance and resilience after disease challenge suggest they may be potential genetic indicators of disease resilience.
Identifiants
pubmed: 34667249
doi: 10.1038/s41598-021-99778-9
pii: 10.1038/s41598-021-99778-9
pmc: PMC8526711
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
20628Informations de copyright
© 2021. The Author(s).
Références
Bioinformatics. 2012 Feb 1;28(3):373-80
pubmed: 22135418
J Dairy Sci. 2013 May;96(5):3285-95
pubmed: 23497994
Front Genet. 2012 Dec 14;3:265
pubmed: 23412990
Poult Sci. 2005 Oct;84(10):1604-9
pubmed: 16335130
Bone. 2004 Jul;35(1):204-9
pubmed: 15207758
Front Genet. 2019 Jan 08;9:660
pubmed: 30671080
J Anim Sci. 2012 Dec;90 Suppl 4:337-9
pubmed: 23365372
PLoS One. 2015 May 27;10(5):e0124219
pubmed: 26017271
J Anim Physiol Anim Nutr (Berl). 2008 Oct;92(5):519-28
pubmed: 19012595
BMC Genomics. 2013 Nov 18;14:798
pubmed: 24246134
Front Mol Biosci. 2020 Dec 11;7:559688
pubmed: 33363202
J Anim Sci. 2017 Aug;95(8):3346-3358
pubmed: 28805915
Front Genet. 2020 Sep 24;11:538600
pubmed: 33193612
J Anim Sci. 2009 Jan;87(1):328-33
pubmed: 18820162
J Anim Sci. 2018 Sep 7;96(9):3791-3803
pubmed: 29931075
Nat Commun. 2020 Jan 7;11(1):39
pubmed: 31911595
Amino Acids. 2014 Apr;46(4):1131-42
pubmed: 24477834
J Thorac Dis. 2016 May;8(5):E305-11
pubmed: 27162688
J Anim Sci. 2020 Aug 1;98(8):
pubmed: 32730570
Amino Acids. 2017 Aug;49(8):1277-1291
pubmed: 28616751
PLoS One. 2011 Feb 16;6(2):e16957
pubmed: 21359215
Cell Biochem Biophys. 2014 Apr;68(3):475-8
pubmed: 24068518
Biomol Ther (Seoul). 2016 Jan;24(1):1-8
pubmed: 26759695
Front Genet. 2020 Mar 13;11:216
pubmed: 32231686
Front Plant Sci. 2019 Jun 28;10:835
pubmed: 31316537
J Physiol Pharmacol. 2008 Aug;59 Suppl 1:91-106
pubmed: 18802218
J Anim Sci. 2014 Dec;92(12):5530-9
pubmed: 25414105
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
Biomed Res Int. 2013;2013:792527
pubmed: 23986911
Appl Environ Microbiol. 2017 Jul 17;83(15):
pubmed: 28526795
Cell Metab. 2012 Jul 3;16(1):9-17
pubmed: 22768835
Twin Res Hum Genet. 2006 Aug;9(4):490-5
pubmed: 16899155
Animal. 2018 May;12(5):1050-1059
pubmed: 29032783
Science. 2009 May 22;324(5930):1076-80
pubmed: 19461003
Nat Genet. 2012 Jan 29;44(3):269-76
pubmed: 22286219
J Lab Clin Med. 1987 May;109(5):566-70
pubmed: 3572204
Sci Rep. 2020 Jan 14;10(1):255
pubmed: 31937890
Animal. 2013 Apr;7(4):571-9
pubmed: 23031189
PLoS One. 2017 May 22;12(5):e0177675
pubmed: 28531195
Immunol Rev. 2012 Sep;249(1):135-57
pubmed: 22889220
Metabolomics. 2018 Jun 8;14(6):83
pubmed: 30830348
J Dairy Sci. 2008 Nov;91(11):4414-23
pubmed: 18946147