Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension.

Acetylcholine / metabolism Angiotensin II Animals Blood Pressure / drug effects Choline O-Acetyltransferase / genetics Disease Models, Animal Heart Rate / drug effects Humans Hypertension / chemically induced Male Mice, Inbred C57BL Nitric Oxide / metabolism Polyethylene Glycols / metabolism Recombinant Proteins / administration & dosage Vasodilation / drug effects
Acetylcholine Choline acetyltransferase Hypertension PEG-ChAT

Journal

Molecular medicine (Cambridge, Mass.)
ISSN: 1528-3658
Titre abrégé: Mol Med
Pays: England
ID NLM: 9501023

Informations de publication

Date de publication:
21 10 2021
Historique:
received: 30 04 2021
accepted: 11 09 2021
entrez: 22 10 2021
pubmed: 23 10 2021
medline: 24 2 2022
Statut: epublish

Résumé

Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations to potentially act upon the endothelium to affect blood pressure. Recently we discovered a T-cell subset expressing ChAT (T

Identifiants

DOI: 10.1186/s10020-021-00380-6 PMID: 34674633 PMC: PMC8529785
pubmed: 34674633
doi: 10.1186/s10020-021-00380-6
pii: 10.1186/s10020-021-00380-6
pmc: PMC8529785
doi:

Substances chimiques

Recombinant Proteins 0
Angiotensin II 11128-99-7
Nitric Oxide 31C4KY9ESH
Polyethylene Glycols 3WJQ0SDW1A
Choline O-Acetyltransferase EC 2.3.1.6
Acetylcholine N9YNS0M02X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

133

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM118182
Pays : United States

Informations de copyright

© 2021. The Author(s).

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Auteurs

Andrew Stiegler (A)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 350 Community Drive, Manhasset, NY, 11030, USA.

Jian-Hua Li (JH)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.

Vivek Shah (V)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.

Tea Tsaava (T)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 350 Community Drive, Manhasset, NY, 11030, USA.

Aisling Tynan (A)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 350 Community Drive, Manhasset, NY, 11030, USA.

Huan Yang (H)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.

Yehuda Tamari (Y)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Circulatory Technology, Inc, 21 Singworth St, Oyster Bay, NY, 11771, USA.

Michael Brines (M)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.

Kevin J Tracey (KJ)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 350 Community Drive, Manhasset, NY, 11030, USA.
The Elmezzi Graduate School of Molecular Medicine, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA.

Sangeeta S Chavan (SS)

Institute of Bioelectronic Medicine, The Feinstein Institutes for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA. schavan@northwell.edu.
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 350 Community Drive, Manhasset, NY, 11030, USA. schavan@northwell.edu.
The Elmezzi Graduate School of Molecular Medicine, Northwell Health, 350 Community Drive, Manhasset, NY, 11030, USA. schavan@northwell.edu.
ORCID: 0000-0002-4822-3356

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Acétylcholine › Systemic administration of choline...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Angiotensines › Angiotensine-II › Systemic administration of choline...
questionsmedicales.fr › Eucaryotes › Animaux › Systemic administration of choline...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Systemic administration of choline...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acetyltransferases › Choline O-acetyltransferase › Systemic administration of choline...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Systemic administration of choline...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Rythme cardiaque › Systemic administration of choline...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Systemic administration of choline...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Systemic administration of choline...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Systemic administration of choline...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Systemic administration of choline...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Systemic administration of choline...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Systemic administration of choline...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Vasodilatation › Systemic administration of choline...