Epitope Mapping of the Anti-CD44 Monoclonal Antibody (C
CD44
epitope mapping
monoclonal antibody
surface plasmon resonance
Journal
Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
22
10
2021
pubmed:
23
10
2021
medline:
14
1
2022
Statut:
ppublish
Résumé
CD44 is a type I transmembrane protein expressed in various kinds of normal cancer cells, including pancreatic, breast, and oral cancers. CD44 is associated with cancer progression, metastases, and treatment resistance. CD44 consists of 20 exons, and various isoforms exist due to alternative splicing of the central 10 exons. Some splicing variants show cancer-specific expression patterns and are related to prognosis of patients with cancer. Therefore, CD44 targeting therapy has been attracting attention. In a previous study, we established an anti-CD44 monoclonal antibody, C
Identifiants
pubmed: 34678095
doi: 10.1089/mab.2021.0028
doi:
Substances chimiques
Antibodies, Monoclonal
0
Hyaluronan Receptors
0
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM