The Relation between Caffeine Consumption and Endometriosis: An Updated Systematic Review and Meta-Analysis.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
29 Sep 2021
Historique:
received: 09 09 2021
revised: 19 09 2021
accepted: 26 09 2021
entrez: 23 10 2021
pubmed: 24 10 2021
medline: 30 11 2021
Statut: epublish

Résumé

While the contributing factors leading to endometriosis remain unclear, its clinical heterogeneity suggests a multifactorial causal background. Amongst others, caffeine has been studied extensively during the last decade as a putative contributing factor. In this systematic review and meta-analysis, we provide an overview/critical appraisal of studies that report on the association between caffeine consumption and the presence of endometriosis. In our search strategy, we screened PubMed and Scopus for human studies examining the above association. The main outcome was the relative risk of endometriosis in caffeine users versus women consuming little or no caffeine (<100 mg/day). Subgroup analyses were conducted for different levels of caffeine intake: high (>300 mg/day) or moderate (100-300 mg/day). Ten studies were included in the meta-analysis (five cohort and five case-control studies). No statistically significant association was observed between overall caffeine consumption and risk for endometriosis (RR 1.12, 95% confidence interval (CI) 0.97-1.28, I

Identifiants

pubmed: 34684458
pii: nu13103457
doi: 10.3390/nu13103457
pmc: PMC8538723
pii:
doi:

Substances chimiques

Coffee 0
Caffeine 3G6A5W338E

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Konstantinos S Kechagias (KS)

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.

Konstantinos Katsikas Triantafyllidis (K)

Department of Dietetics, West Suffolk Hospital NHS Foundation Trust, Bury St Edmunds, Bury Saint Edmunds IP33 2QZ, UK.
Society of Meta-Research and Biomedical Innovation, London W12 0BZ, UK.

Margarita Kyriakidou (M)

Department of Applied Mathematical and Physical Sciences, National Technical University of Athens, 15773 Athens, Greece.

Panagiotis Giannos (P)

Society of Meta-Research and Biomedical Innovation, London W12 0BZ, UK.
Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UK.

Ilkka Kalliala (I)

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
Department of Obstetrics and Gynaecology, Helsinki University and University Hospital Helsinki, 00014 Helsinki, Finland.

Areti Angeliki Veroniki (AA)

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
Knowledge Translation Program, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.

Maria Paraskevaidi (M)

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.

Maria Kyrgiou (M)

Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
West London Gynaecological Cancer Centre, Imperial College NHS Trust, London W12 0HS, UK.

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