New-onset Evans syndrome associated with systemic lupus erythematosus after BNT162b2 mRNA COVID-19 vaccination.
Anemia, Hemolytic, Autoimmune
/ diagnosis
BNT162 Vaccine
/ adverse effects
Female
Hematologic Tests
/ methods
Hemoglobins
Humans
Lupus Erythematosus, Systemic
/ diagnosis
Middle Aged
Platelet Count
Prednisolone
/ administration & dosage
Purpura, Thrombocytopenic, Idiopathic
Risk Assessment
Thrombocytopenia
/ diagnosis
Vaccination
/ adverse effects
AIHA
COVID-19 mRNA vaccine
Evans syndrome
ITP
SLE
Journal
International journal of hematology
ISSN: 1865-3774
Titre abrégé: Int J Hematol
Pays: Japan
ID NLM: 9111627
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
25
07
2021
accepted:
17
10
2021
revised:
15
10
2021
pubmed:
24
10
2021
medline:
12
3
2022
entrez:
23
10
2021
Statut:
ppublish
Résumé
Evans syndrome presents as concurrent autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). Systemic lupus erythematosus (SLE) is the most frequent autoimmune disorder associated with Evans syndrome. We herein report a case of new-onset Evans syndrome associated with SLE after BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccination in a 53-year-old woman. Blood examination at diagnosis showed hemolytic anemia with a positive Coombs test and thrombocytopenia. Hypocomplementemia and the presence of lupus anticoagulant indicated a strong association with SLE. Prednisolone administration rapidly restored hemoglobin level and platelet count. This case suggests that mRNA COVID-19 vaccination may cause an autoimmune disorder. Physicians should be aware of this adverse reaction by mRNA COVID-19 vaccination and should consider the benefits and risks of vaccination for each recipient.
Identifiants
pubmed: 34687421
doi: 10.1007/s12185-021-03243-2
pii: 10.1007/s12185-021-03243-2
pmc: PMC8536917
doi:
Substances chimiques
Hemoglobins
0
Prednisolone
9PHQ9Y1OLM
BNT162 Vaccine
N38TVC63NU
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-427Informations de copyright
© 2021. Japanese Society of Hematology.
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