Compartmentalized cAMP signaling in cardiac ventricular myocytes.
Buffering
Cardiac myocytes
Phosphodiesterase
Prostaglandin receptor
Protein kinase A
Restricted spaces
beta-Adrenergic receptor
cAMP compartmentation
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
31
08
2021
revised:
15
10
2021
accepted:
17
10
2021
pubmed:
24
10
2021
medline:
1
4
2022
entrez:
23
10
2021
Statut:
ppublish
Résumé
Activation of different receptors that act by generating the common second messenger cyclic adenosine monophosphate (cAMP) can elicit distinct functional responses in cardiac myocytes. Selectively sequestering cAMP activity to discrete intracellular microdomains is considered essential for generating receptor-specific responses. The processes that control this aspect of compartmentalized cAMP signaling, however, are not completely clear. Over the years, technological innovations have provided critical breakthroughs in advancing our understanding of the mechanisms underlying cAMP compartmentation. Some of the factors identified include localized production of cAMP by differential distribution of receptors, localized breakdown of this second messenger by targeted distribution of phosphodiesterase enzymes, and limited diffusion of cAMP by protein kinase A (PKA)-dependent buffering or physically restricted barriers. The aim of this review is to provide a discussion of our current knowledge and highlight some of the gaps that still exist in the field of cAMP compartmentation in cardiac myocytes.
Identifiants
pubmed: 34687901
pii: S0898-6568(21)00261-8
doi: 10.1016/j.cellsig.2021.110172
pmc: PMC8602782
mid: NIHMS1751242
pii:
doi:
Substances chimiques
Cyclic AMP
E0399OZS9N
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
110172Subventions
Organisme : NIH HHS
ID : OT2 OD023848
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM130459
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM107094
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL145778
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
J Biol Chem. 2005 Sep 2;280(35):31036-44
pubmed: 15961389
J Clin Invest. 1996 Jul 15;98(2):556-62
pubmed: 8755668
Science. 2002 Oct 25;298(5594):834-6
pubmed: 12399592
Circ Res. 2013 Jan 18;112(2):289-97
pubmed: 23168336
Science. 2002 Mar 1;295(5560):1711-5
pubmed: 11872839
Cell. 2002 Sep 20;110(6):737-49
pubmed: 12297047
J Biol Chem. 2004 May 7;279(19):19846-53
pubmed: 15007069
Nat Cell Biol. 2000 Jan;2(1):25-9
pubmed: 10620803
Circ Res. 2007 Apr 13;100(7):950-66
pubmed: 17431197
Mol Pharmacol. 2003 Sep;64(3):533-46
pubmed: 12920188
Circ Res. 1999 Jan 8-22;84(1):43-52
pubmed: 9915773
Annu Rev Pharmacol Toxicol. 2013;53:187-210
pubmed: 23043438
Basic Res Cardiol. 2011 Mar;106(2):249-62
pubmed: 21161247
Circ Res. 2008 May 9;102(9):1091-100
pubmed: 18369156
Cells. 2019 Aug 27;8(9):
pubmed: 31461851
Br J Pharmacol. 2021 Apr;178(7):1574-1587
pubmed: 33475150
J Biol Chem. 2002 Sep 13;277(37):34280-6
pubmed: 12097322
J Mol Cell Cardiol. 2011 Mar;50(3):500-9
pubmed: 21115018
Mol Pharmacol. 1988 Jun;33(6):664-71
pubmed: 2454387
J Mol Cell Cardiol. 1992 Jul;24(7):669-81
pubmed: 1404407
J Cardiovasc Dev Dis. 2018 Mar 13;5(1):
pubmed: 29533995
Br J Pharmacol. 1999 May;127(1):65-74
pubmed: 10369457
Circ Res. 2006 Apr 28;98(8):993-1001
pubmed: 16645149
Cell Commun Signal. 2013 Aug 28;11:64
pubmed: 23984976
Nature. 1991 Feb 21;349(6311):694-7
pubmed: 1847505
Elife. 2019 Aug 21;8:
pubmed: 31433293
J Biol Chem. 1999 Jul 30;274(31):22048-52
pubmed: 10419531
J Cell Sci. 2014 Mar 1;127(Pt 5):1033-42
pubmed: 24413164
J Physiol. 2007 May 1;580(Pt.3):765-76
pubmed: 17289786
J Physiol. 1997 Feb 15;499 ( Pt 1):105-20
pubmed: 9061643
J Biol Chem. 2002 Oct 11;277(41):38072-8
pubmed: 12154085
Annu Rev Biochem. 2007;76:481-511
pubmed: 17376027
J Cardiovasc Dev Dis. 2018 May 03;5(2):
pubmed: 29751502
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):940-5
pubmed: 12552097
J Mol Cell Cardiol. 2012 Feb;52(2):323-9
pubmed: 21888909
Annu Rev Pharmacol Toxicol. 2001;41:751-73
pubmed: 11264475
Cell Calcium. 2005 Jul;38(1):1-9
pubmed: 15993240
Nat Protoc. 2011 Apr;6(4):427-38
pubmed: 21412271
Am J Physiol Renal Physiol. 2000 Sep;279(3):F400-16
pubmed: 10966920
J Biol Chem. 2011 Dec 2;286(48):41520-41529
pubmed: 21965681
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10414-10419
pubmed: 28893983
Circ Res. 1997 Mar;80(3):297-304
pubmed: 9048648
Cardiovasc Res. 2019 Mar 1;115(3):546-555
pubmed: 30165515
Circulation. 2015 Dec 22;132(25):2372-84
pubmed: 26450916
J Physiol. 2001 Jan 1;530(Pt 1):79-91
pubmed: 11136860
PLoS Comput Biol. 2016 Jul 13;12(7):e1005005
pubmed: 27409243
J Biol Chem. 1977 Jun 10;252(11):3854-61
pubmed: 16921
J Biol Chem. 2007 Nov 9;282(45):32749-57
pubmed: 17726023
Circ Res. 2015 Sep 25;117(8):707-19
pubmed: 26243800
Curr Opin Cell Biol. 2005 Apr;17(2):129-34
pubmed: 15780588
J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606
pubmed: 23810893
Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1343-8
pubmed: 18671712
Elife. 2020 Mar 31;9:
pubmed: 32228862
Circ Res. 2011 Apr 15;108(8):929-39
pubmed: 21330599
Nat Protoc. 2010 Nov;5(11):1761-74
pubmed: 21030952
Am J Physiol Cell Physiol. 2008 Aug;295(2):C414-22
pubmed: 18550706
Proc Natl Acad Sci U S A. 1979 Apr;76(4):1570-4
pubmed: 221898
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3580-3
pubmed: 4372627
Circulation. 2004 May 25;109(20):2462-8
pubmed: 15123528
Cardiovasc Res. 2008 Jan 15;77(2):237-44
pubmed: 18006490
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7500-5
pubmed: 16648270
Sci Rep. 2017 Jul 17;7(1):5522
pubmed: 28717248
J Gen Physiol. 2000 Aug;116(2):147-61
pubmed: 10919863
Circ Res. 2009 Nov 6;105(10):956-64
pubmed: 19797176
Cell. 2005 Oct 7;123(1):25-35
pubmed: 16213210
BMC Biochem. 2008 Jun 25;9:18
pubmed: 18578870
J Mol Cell Cardiol. 1987 Oct;19(10):1025-36
pubmed: 2830402
Mitochondrion. 2019 Jul;47:64-75
pubmed: 31100470
J Biol Chem. 2004 Sep 3;279(36):37215-8
pubmed: 15231839
Am J Physiol Cell Physiol. 2005 Aug;289(2):C455-61
pubmed: 15788489
Biophys J. 2007 May 1;92(9):3317-31
pubmed: 17293406
Circ Res. 2006 Apr 28;98(8):1081-8
pubmed: 16556871
Mol Pharmacol. 2000 May;57(5):1075-9
pubmed: 10779394
Cardiovasc Res. 2016 Jun 1;110(3):395-407
pubmed: 27089919
J Physiol. 2001 Nov 1;536(Pt 3):677-92
pubmed: 11691864
Br J Pharmacol. 2004 Sep;143(2):235-45
pubmed: 15289291
Nature. 1979 Jul 5;280(5717):78-80
pubmed: 15305586
Cell. 2020 Sep 17;182(6):1519-1530.e17
pubmed: 32846156
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14997-5002
pubmed: 11752448
Nature. 1997 Nov 6;390(6655):88-91
pubmed: 9363896
Eur J Pharmacol. 1992 Mar 12;225(3):263-72
pubmed: 1325367
J Mol Cell Cardiol. 1997 Nov;29(11):3135-46
pubmed: 9405187
Physiology (Bethesda). 2006 Dec;21:430-9
pubmed: 17119156
EMBO J. 2008 Jan 23;27(2):384-93
pubmed: 18188154
Circ Res. 1999 Nov 26;85(11):1101-11
pubmed: 10571542
J Mol Cell Cardiol. 2020 Jan;138:99-109
pubmed: 31783032
J Biol Chem. 2003 Feb 21;278(8):5493-6
pubmed: 12493749
Physiol Rev. 2007 Jul;87(3):965-1010
pubmed: 17615394
J Biol Chem. 2004 Dec 10;279(50):52095-105
pubmed: 15466415
Front Pharmacol. 2018 Apr 23;9:332
pubmed: 29740315
J Biol Chem. 2005 Nov 25;280(47):39168-74
pubmed: 16172121
Circ Res. 2010 Sep 17;107(6):747-56
pubmed: 20671242
J Biol Chem. 2001 Nov 9;276(45):42063-9
pubmed: 11533056
Mol Cell. 2011 Apr 8;42(1):84-95
pubmed: 21474070
Biophys J. 2000 Nov;79(5):2682-91
pubmed: 11053140
J Biol Chem. 1980 Jun 10;255(11):5113-9
pubmed: 6154700
J Biol Chem. 1994 Jul 22;269(29):19151-6
pubmed: 8034672
Cell. 2004 Aug 6;118(3):375-87
pubmed: 15294162
PLoS One. 2012;7(10):e47652
pubmed: 23077656
Nat Rev Mol Cell Biol. 2012 Oct;13(10):646-58
pubmed: 22992589
J Mol Cell Cardiol. 2012 Feb;52(2):366-75
pubmed: 21782827
J Biol Chem. 2006 Jul 28;281(30):21500-21511
pubmed: 16728394
Cell Rep. 2016 Jan 5;14(1):140-151
pubmed: 26725114
J Biol Chem. 2006 Sep 8;281(36):26391-9
pubmed: 16818493
Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12923-8
pubmed: 16905651
Circ Res. 2004 Jul 9;95(1):67-75
pubmed: 15178638
Cardiovasc Drugs Ther. 2007 Jun;21(3):171-94
pubmed: 17373584
Physiol Rep. 2021 Sep;9(17):e15015
pubmed: 34514737
Science. 2010 Mar 26;327(5973):1653-7
pubmed: 20185685
J Mol Cell Cardiol. 2011 May;50(5):872-83
pubmed: 21334344
Science. 2017 Jun 23;356(6344):1288-1293
pubmed: 28642438
Physiol Rev. 2011 Apr;91(2):651-90
pubmed: 21527734
J Biol Chem. 2012 Aug 24;287(35):29815-24
pubmed: 22778270
J Biol Chem. 2000 Dec 29;275(52):41447-57
pubmed: 11006286
Circ Res. 2006 Feb 3;98(2):226-34
pubmed: 16357307
J Biol Chem. 2003 Nov 28;278(48):47997-8003
pubmed: 12972422
Br J Pharmacol. 2003 Jul;139(6):1074-84
pubmed: 12871825
J Cardiovasc Electrophysiol. 1998 Jul;9(7):718-26
pubmed: 9684720
Biochem J. 1997 Dec 1;328 ( Pt 2):539-48
pubmed: 9371713
Biochem J. 2003 Feb 15;370(Pt 1):1-18
pubmed: 12444918
Circ Res. 2006 Nov 10;99(10):1084-91
pubmed: 17038640
J Diabetes Res. 2016;2016:1324347
pubmed: 27190998
Circ Res. 2021 Jun 25;129(1):81-94
pubmed: 33902292
Sci Rep. 2016 Jan 22;6:19577
pubmed: 26795432
Nat Rev Neurosci. 2007 Feb;8(2):128-40
pubmed: 17195035
Science. 2002 Jan 18;295(5554):496-9
pubmed: 11799244
Circulation. 1999 May 11;99(18):2458-65
pubmed: 10318670
J Mol Cell Cardiol. 2012 Feb;52(2):388-400
pubmed: 21740911
Pharmacol Ther. 2006 Mar;109(3):366-98
pubmed: 16102838
Circ Res. 2021 Jan 22;128(2):246-261
pubmed: 33183171
J Clin Invest. 2011 Jul;121(7):2651-61
pubmed: 21670503
Circ Res. 2015 Apr 10;116(8):1304-11
pubmed: 25688144
Pharmacol Rev. 2002 Sep;54(3):431-67
pubmed: 12223531
Circ Res. 2009 Oct 9;105(8):784-92
pubmed: 19745166
Mol Pharmacol. 1995 Feb;47(2):322-9
pubmed: 7870040
Cardiovasc Res. 2013 May 1;98(2):269-76
pubmed: 23405000