Proposed diagnostic criteria for mild cognitive impairment in Down syndrome population.
Down syndrome
cognition
dementia
mild cognitive impairment
prodromal stages
Journal
Journal of applied research in intellectual disabilities : JARID
ISSN: 1468-3148
Titre abrégé: J Appl Res Intellect Disabil
Pays: England
ID NLM: 9613616
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
revised:
08
10
2021
received:
23
08
2020
accepted:
08
10
2021
pubmed:
26
10
2021
medline:
19
2
2022
entrez:
25
10
2021
Statut:
ppublish
Résumé
Despite presenting higher risk of dementia, mild cognitive impairment (MCI) is not well defined in Down syndrome population. We aimed to describe cognitive and neuropsychological patterns associated with MCI in Down syndrome individuals. Two groups of adults with Down syndrome (control and prodromal) were studied throughout 3 years. Two linear mixed models and a model including the variables that best predicted group membership were built. Behavioural Regulation Index (BRI) (Behaviour Rating Inventory of Executive Function test) and the model composed of BRI, abstraction and delayed verbal memory were the variable and model best predicting group membership, respectively. Suggest a diagnosis of MCI when BRI is the earliest change perceived by caregivers and this is combined with low scores in abstract thinking, and when an amnesic pattern in delayed verbal memory is observed, but adaptive skills are preserved.
Sections du résumé
BACKGROUND
BACKGROUND
Despite presenting higher risk of dementia, mild cognitive impairment (MCI) is not well defined in Down syndrome population.
OBJECTIVE
OBJECTIVE
We aimed to describe cognitive and neuropsychological patterns associated with MCI in Down syndrome individuals.
METHOD
METHODS
Two groups of adults with Down syndrome (control and prodromal) were studied throughout 3 years. Two linear mixed models and a model including the variables that best predicted group membership were built.
RESULTS
RESULTS
Behavioural Regulation Index (BRI) (Behaviour Rating Inventory of Executive Function test) and the model composed of BRI, abstraction and delayed verbal memory were the variable and model best predicting group membership, respectively.
CONCLUSION
CONCLUSIONS
Suggest a diagnosis of MCI when BRI is the earliest change perceived by caregivers and this is combined with low scores in abstract thinking, and when an amnesic pattern in delayed verbal memory is observed, but adaptive skills are preserved.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
495-505Subventions
Organisme : Institute of Health Carlos III
ID : PI12/02019
Organisme : Ministry of Economy and Competitiveness
Informations de copyright
© 2021 John Wiley & Sons Ltd.
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