The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorectal cancer: A systematic review and meta-analysis.
Colorectal Neoplasms
/ pathology
Combined Modality Therapy
Cytoreduction Surgical Procedures
/ methods
Humans
Hyperthermia, Induced
/ methods
Hyperthermic Intraperitoneal Chemotherapy
Muscle, Skeletal
/ pathology
Peritoneal Neoplasms
/ secondary
Postoperative Complications
/ etiology
Prognosis
Prospective Studies
Survival Rate
Body composition
Clinical nutrition
Clinical outcomes
HIPEC
Peritoneal metastases
Sarcopenia
Journal
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
ISSN: 1532-2157
Titre abrégé: Eur J Surg Oncol
Pays: England
ID NLM: 8504356
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
22
02
2021
revised:
30
09
2021
accepted:
12
10
2021
pubmed:
27
10
2021
medline:
6
5
2022
entrez:
26
10
2021
Statut:
ppublish
Résumé
Cytoreductive surgery (CRS) and hypertermic intraperitoneal chemotherapy (HIPEC) represent the most effective strategy to manage peritoneal metastases (PM). This systematic review and meta-analysis aimed to assess the impact of body composition on clinical outcomes in patients with PM. A systematic literature search was performed using Medline, Web of Science and EMBASE databases from inception to the 20 A total of 4 studies were included in the systematic review and meta-analysis, including 582 patients. A significant association between low skeletal muscle mass and POC was found (OR 1.45, 95% CI 1.04 to 2.03; p = 0.03), while no differences were found in terms operative time, estimated blood loss, length of hospital stay, and postoperative mortality (p > 0.05). Low skeletal muscle mass at diagnosis is a valid prognostic factor for POC development in colorectal and PM patients undergoing CRS. Prospective and larger studies are needed to better investigate the role of CT scan derived body composition and to understand how to implement this tool in clinical practice.
Sections du résumé
BACKGROUND
BACKGROUND
Cytoreductive surgery (CRS) and hypertermic intraperitoneal chemotherapy (HIPEC) represent the most effective strategy to manage peritoneal metastases (PM). This systematic review and meta-analysis aimed to assess the impact of body composition on clinical outcomes in patients with PM.
METHODS
METHODS
A systematic literature search was performed using Medline, Web of Science and EMBASE databases from inception to the 20
RESULTS
RESULTS
A total of 4 studies were included in the systematic review and meta-analysis, including 582 patients. A significant association between low skeletal muscle mass and POC was found (OR 1.45, 95% CI 1.04 to 2.03; p = 0.03), while no differences were found in terms operative time, estimated blood loss, length of hospital stay, and postoperative mortality (p > 0.05).
CONCLUSIONS
CONCLUSIONS
Low skeletal muscle mass at diagnosis is a valid prognostic factor for POC development in colorectal and PM patients undergoing CRS. Prospective and larger studies are needed to better investigate the role of CT scan derived body composition and to understand how to implement this tool in clinical practice.
Identifiants
pubmed: 34696936
pii: S0748-7983(21)00763-0
doi: 10.1016/j.ejso.2021.10.008
pii:
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
649-656Informations de copyright
Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None of the Author have nothing to declare.