Synthetic Natural Product Inspired Cyclic Peptides.

Anti-Bacterial Agents / chemistry Biological Products / chemistry Computational Biology Cyclization Drug Discovery Drug Resistance, Multiple, Bacterial / drug effects Microbial Sensitivity Tests Multigene Family Penicillin-Binding Proteins / chemistry Peptides, Cyclic / chemistry Solid-Phase Synthesis Techniques

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
19 11 2021
Historique:
pubmed: 27 10 2021
medline: 1 2 2022
entrez: 26 10 2021
Statut: ppublish

Résumé

Natural products are a bountiful source of bioactive molecules. Unfortunately, discovery of novel bioactive natural products is challenging due to cryptic biosynthetic gene clusters, low titers, and arduous purifications. Herein, we describe SNaPP (

Identifiants

DOI: 10.1021/acschembio.1c00641 PMID: 34699170 PMC: PMC8610019
pubmed: 34699170
doi: 10.1021/acschembio.1c00641
pmc: PMC8610019
doi:

Substances chimiques

Anti-Bacterial Agents 0
Biological Products 0
Penicillin-Binding Proteins 0
Peptides, Cyclic 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2604-2611

Subventions

Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM138002
Pays : United States

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Auteurs

Matthew A Hostetler (MA)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Chloe Smith (C)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Samantha Nelson (S)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.

Zachary Budimir (Z)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Ramya Modi (R)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Ian Woolsey (I)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Autumn Frerk (A)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Braden Baker (B)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Jessica Gantt (J)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.

Elizabeth I Parkinson (EI)

Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.
ORCID: 0000-0002-3665-5522

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Métabolisme › Cyclisation › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Multirésistance aux médicaments › Multirésistance bactérienne aux médicaments › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines de liaison aux pénicillines › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Synthetic Natural Product Inspired Cyclic Peptides.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Techniques de synthèse en phase solide › Synthetic Natural Product Inspired Cyclic Peptides.