Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle.
Adult
Blood Glucose
/ metabolism
Calorimetry
Cross-Over Studies
Dietary Fats
/ administration & dosage
Diglycerides
/ blood
Fatty Acids
/ blood
Female
Glucose Clamp Technique
Healthy Volunteers
Humans
Insulin Resistance
/ physiology
Male
Muscle, Skeletal
/ metabolism
Oleic Acid
/ administration & dosage
Palm Oil
/ administration & dosage
Palmitates
/ administration & dosage
Protein Kinase C
/ blood
Safflower Oil
/ administration & dosage
Young Adult
Glucose metabolism
Insulin signalling
Lipotoxicity
Monounsaturated fatty acids
Saturated fat
Skeletal muscle
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
17
05
2021
accepted:
16
08
2021
pubmed:
28
10
2021
medline:
26
3
2022
entrez:
27
10
2021
Statut:
ppublish
Résumé
Energy-dense nutrition generally induces insulin resistance, but dietary composition may differently affect glucose metabolism. This study investigated initial effects of monounsaturated vs saturated lipid meals on basal and insulin-stimulated myocellular glucose metabolism and insulin signalling. In a randomised crossover study, 16 lean metabolically healthy volunteers received single meals containing safflower oil (SAF), palm oil (PAL) or vehicle (VCL). Whole-body glucose metabolism was assessed from glucose disposal (R SAF and PAL raised plasma oleate, but only PAL significantly increased plasma palmitate concentrations. SAF and PAL increased myocellular diacylglycerol and activated protein kinase C (PKC) isoform θ (p < 0.05) but only PAL activated PKCɛ. Moreover, PAL led to increased myocellular ceramides along with stimulated PKCζ translocation (p < 0.05 vs SAF). During clamp, SAF and PAL both decreased insulin-stimulated R Lipid-induced myocellular insulin resistance is likely more pronounced with palmitate than with oleate and is associated with PKC isoforms activation and inhibitory insulin signalling. ClinicalTrials.gov .NCT01736202. German Federal Ministry of Health, Ministry of Culture and Science of the State North Rhine-Westphalia, German Federal Ministry of Education and Research, European Regional Development Fund, German Research Foundation, German Center for Diabetes Research.
Identifiants
pubmed: 34704121
doi: 10.1007/s00125-021-05596-z
pii: 10.1007/s00125-021-05596-z
pmc: PMC8741704
doi:
Substances chimiques
Blood Glucose
0
Dietary Fats
0
Diglycerides
0
Fatty Acids
0
Palmitates
0
Oleic Acid
2UMI9U37CP
Palm Oil
5QUO05548Z
Safflower Oil
8001-23-8
Protein Kinase C
EC 2.7.11.13
Banques de données
ClinicalTrials.gov
['NCT01736202']
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
301-314Informations de copyright
© 2021. The Author(s).
Références
Diabetologia. 2008 Jul;51(7):1253-60
pubmed: 18458871
Diabetologia. 2006 Jun;49(6):1371-9
pubmed: 16596361
Diabetes. 2002 Jul;51(7):2005-11
pubmed: 12086926
Diabetes. 1999 Jun;48(6):1270-4
pubmed: 10342815
Biochim Biophys Acta. 2012 May;1821(5):721-6
pubmed: 22281699
Diabetes. 2010 Oct;59(10):2453-64
pubmed: 20522596
Sci Adv. 2021 Oct 8;7(41):eabi9551
pubmed: 34623918
Am J Physiol Endocrinol Metab. 2001 Feb;280(2):E229-37
pubmed: 11158925
Nature. 2019 Dec;576(7785):51-60
pubmed: 31802013
Diabetologia. 2014 Mar;57(3):572-81
pubmed: 24310562
Diabetes. 1975 Jan;24(1):10-6
pubmed: 1120541
J Clin Invest. 1996 Feb 1;97(3):642-8
pubmed: 8609218
J Cell Physiol. 2010 Nov;225(3):786-91
pubmed: 20568228
J Lipid Res. 1986 Jan;27(1):114-20
pubmed: 3958609
JCI Insight. 2020 May 21;5(10):
pubmed: 32434996
J Biol Chem. 2004 Aug 27;279(35):36608-15
pubmed: 15220355
Diabetes. 2004 May;53(5):1215-21
pubmed: 15111489
J Clin Invest. 2019 Oct 1;129(10):3969-3970
pubmed: 31449059
Trends Endocrinol Metab. 2012 Aug;23(8):391-8
pubmed: 22721584
Diabetes. 2003 Dec;52(12):2882-7
pubmed: 14633847
PLoS One. 2012;7(6):e39029
pubmed: 22761721
Diabetes. 2013 Apr;62(4):1054-63
pubmed: 23238293
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Diabetologia. 2002 Jun;45(6):813-22
pubmed: 12107725
Diabetes. 2013 Jul;62(7):2240-8
pubmed: 23454694
J Biol Chem. 1999 Aug 20;274(34):24202-10
pubmed: 10446195
Diabetologia. 2012 Apr;55(4):1140-50
pubmed: 22252470
J Clin Invest. 2017 Feb 1;127(2):695-708
pubmed: 28112681
J Clin Endocrinol Metab. 2011 Apr;96(4):E691-5
pubmed: 21252252
Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):2000-2010
pubmed: 27725263
J Biol Chem. 2004 Oct 29;279(44):45304-7
pubmed: 15364919
Diabetes. 2006 Jan;55(1):136-40
pubmed: 16380486
Am J Physiol Endocrinol Metab. 2014 Dec 15;307(12):E1117-24
pubmed: 25352435
Diabetes. 2017 Aug;66(8):2082-2091
pubmed: 28483801
Diabetes. 2005 Mar;54(3):648-56
pubmed: 15734839
Diabetologia. 2001 Jun;44(6):659-73
pubmed: 11440359
Br J Nutr. 2009 Dec;102(11):1557-63
pubmed: 19622194
Cells. 2019 Mar 22;8(3):
pubmed: 30909521
J Clin Invest. 2004 Sep;114(6):823-7
pubmed: 15372106
Diabetes. 2010 Mar;59(3):600-10
pubmed: 19959757
JCI Insight. 2018 Feb 8;3(3):
pubmed: 29415895
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9597-602
pubmed: 24979806
Front Endocrinol (Lausanne). 2020 Aug 07;11:491
pubmed: 32849282
Biochim Biophys Acta. 2016 Jan;1861(1):12-20
pubmed: 26477381
Arch Biochem Biophys. 2003 Nov 15;419(2):101-9
pubmed: 14592453
J Clin Endocrinol Metab. 2007 Apr;92(4):1524-9
pubmed: 17264178
J Clin Invest. 2009 Mar;119(3):573-81
pubmed: 19188683
Diabetes Care. 2018 Jan;41(Suppl 1):S38-S50
pubmed: 29222375