Cardiovascular magnetic resonance findings in non-hospitalized paediatric patients after recovery from COVID-19.
CMR
COVID-19
Inflammation
Myocarditis
Paediatric
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
01
10
2021
received:
18
06
2021
accepted:
05
10
2021
pubmed:
28
10
2021
medline:
5
1
2022
entrez:
27
10
2021
Statut:
ppublish
Résumé
Our study aimed to investigate the cardiac involvement with sensitive tissue characterization in non-hospitalized children with coronavirus disease 2019 (COVID-19) infection using cardiovascular magnetic resonance (CMR) imaging. We prospectively enrolled children who recovered from mildly symptomatic COVID-19 infection between November 2020 and January 2021. Patients underwent CMR at 1.5 T (Achieva, Philips Healthcare, Best, the Netherlands) including cine images, native T1 and T2 mapping. Healthy children and paediatric patients with biopsy-proven myocarditis served as control groups. We performed CMR in 18 children with a median (25th-75th percentile) age of 12 (10-15) years, 38 (24-47) days after positive PCR test, and compared them with 7 healthy controls [15 (10-19) years] and 9 patients with myocarditis [10 (4-16) years]. The COVID-19 patients reported no cardiac symptoms. None of the COVID-19 patients showed CMR findings consistent with a myocarditis. Three patients (17%) from the COVID-19 cohort presented with minimal pericardial effusion. CMR parameters of COVID-19 patients, including volumetric and strain values as well as T1 and T2 times, were not significantly different from healthy controls, but from myocarditis patients. These had significantly reduced left ventricular (LV) ejection fraction (P = 0.035), LV global longitudinal strain, and left atrial strain values as well as elevated native T1 values compared with COVID-19 patients (P < 0.001, respectively). There was no evidence of myocardial inflammation, fibrosis, or functional cardiac impairment in the studied cohort of children recently. CMR findings were comparable with those of healthy controls. Pericardial effusion suggests a mild pericarditis in a small subgroup. This is pointing to a minor clinical relevance of myocardial involvement in children after mildly symptomatic COVID-19 infections.
Identifiants
pubmed: 34704672
doi: 10.1002/ehf2.13678
pmc: PMC8652950
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5583-5588Informations de copyright
© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.
Références
ESC Heart Fail. 2021 Dec;8(6):5583-5588
pubmed: 34704672
Int J Cardiol. 2021 Jun 15;333:219-225
pubmed: 33737165
JAMA Cardiol. 2020 Nov 01;5(11):1265-1273
pubmed: 32730619
Eur Heart J Cardiovasc Imaging. 2021 Jul 20;22(8):844-851
pubmed: 33686389
Am Heart J. 2017 May;187:133-144
pubmed: 28454797
Eur Heart J Cardiovasc Imaging. 2021 Jul 20;22(8):852-854
pubmed: 34080005
JACC Cardiovasc Imaging. 2020 Nov;13(11):2330-2339
pubmed: 32763118
Eur Heart J Cardiovasc Imaging. 2021 Jul 20;22(8):896-903
pubmed: 32766671
Pediatr Radiol. 2020 Sep;50(10):1354-1368
pubmed: 32749530
Circulation. 2021 Jan 5;143(1):21-32
pubmed: 33166189
J Cardiovasc Magn Reson. 2021 Feb 25;23(1):14
pubmed: 33627143
Pediatrics. 2021 Feb;147(2):
pubmed: 33234669
J Magn Reson Imaging. 2022 Mar;55(3):866-880
pubmed: 34309139
Heart. 2020 Aug;106(15):1127-1131
pubmed: 32499236