Inhibitors of sodium-glucose transport protein 2: A new multidirectional therapeutic option for heart failure patients.
dapagliflozin
empagliflozin
heart failure
mechanisms
sodium-glucose co-transporters (SGLTs)
Journal
Cardiology journal
ISSN: 1898-018X
Titre abrégé: Cardiol J
Pays: Poland
ID NLM: 101392712
Informations de publication
Date de publication:
2023
2023
Historique:
received:
19
07
2021
accepted:
06
08
2021
pubmed:
29
10
2021
medline:
4
3
2023
entrez:
28
10
2021
Statut:
ppublish
Résumé
Several mechanisms have been suggested to explain positive cardiovascular effects observed in studies with sodium-glucose co-transporter 2 (SGLT2) inhibitors. The reduction in glucose reabsorption in proximal tubuli induced by SGLT2 inhibitors increases urinary glucose and sodium excretion resulting in increased osmotic diuresis and consequently in decreased plasma volume, followed by reduced preload. In addition, the hemodynamic effects of SGLT2 inhibition were observed in both hyper and euglycemic patients. Due to the complex and multidirectional effects induced by SGLT2 inhibitors, this originally antidiabetic group of drugs has been successfully used to treat patients with heart failure as well as for subjects with chronic kidney disease. Moreover, their therapeutic potential seems to be even broader than the indications studied to date.
Identifiants
pubmed: 34708866
pii: VM/OJS/J/84836
doi: 10.5603/CJ.a2021.0133
pmc: PMC9987542
doi:
Substances chimiques
Sodium-Glucose Transporter 2 Inhibitors
0
Sodium-Glucose Transporter 2
0
Glucosides
0
Hypoglycemic Agents
0
Sodium
9NEZ333N27
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
143-149Références
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