[Local administration of parathyroid hormone and parathyroid hormone-related peptides for bone tissue engineering].
bone healing
bone regeneration
local delivery strategies
parathyroid hormone
parathyroid hormone-related peptides
Journal
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
ISSN: 1001-5515
Titre abrégé: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Pays: China
ID NLM: 9426398
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
3
11
2021
Statut:
ppublish
Résumé
Parathyroid hormone (PTH) exerts multiple effects such as regulating bone remodeling, promoting angiogenesis, etc., and it is an active factor with great application potential for bone repair. In recent years, with the development of scaffold material loading strategies and parathyroid hormone-related peptides (PTHrPs), in situ loading of PTH or PTHrPs on scaffold materials to promote bone defect healing gradually becomes possible. Based on the current status and challenges of intermittent PTH (iPTH) for bone tissue engineering, the review summarizes the in-situ application strategies of PTH and the construction of PTHrPs as well as current problems and further directions in this field, with a view to propel the clinical application of scaffold materials loaded with PTH or PTHrPs 甲状旁腺素（PTH）具有调节骨重构、促血管生成等多重作用，是一种极具应用潜力的骨修复活性因子。近年来，随着支架材料负载策略、甲状旁腺素相关肽（PTHrPs）的发展，支架材料原位负载 PTH 或 PTHrPs 治疗促进骨缺损愈合逐渐成为可能。本文基于系统间歇性 PTH（iPTH）应用于骨组织工程的现状与挑战，就 PTH 的原位负载策略及 PTHrPs 的构建两方面进行阐述，并探讨了该领域存在的问题及未来的研究方向，以期促进支架材料原位负载 PTH 或 PTHrPs 的临床应用。.
Autres résumés
Type: Publisher
(chi)
甲状旁腺素（PTH）具有调节骨重构、促血管生成等多重作用，是一种极具应用潜力的骨修复活性因子。近年来，随着支架材料负载策略、甲状旁腺素相关肽（PTHrPs）的发展，支架材料原位负载 PTH 或 PTHrPs 治疗促进骨缺损愈合逐渐成为可能。本文基于系统间歇性 PTH（iPTH）应用于骨组织工程的现状与挑战，就 PTH 的原位负载策略及 PTHrPs 的构建两方面进行阐述，并探讨了该领域存在的问题及未来的研究方向，以期促进支架材料原位负载 PTH 或 PTHrPs 的临床应用。.
Identifiants
pubmed: 34713672
doi: 10.7507/1001-5515.202104045
pmc: PMC9927431
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Journal Article
Review
Langues
chi
Sous-ensembles de citation
IM
Pagination
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