Treatment of systemic sclerosis.

Heart Diseases / etiology Hematopoietic Stem Cell Transplantation Humans Immunosuppressive Agents / therapeutic use Lung Diseases, Interstitial / etiology Precision Medicine Prognosis Pulmonary Arterial Hypertension / etiology Randomized Controlled Trials as Topic Scleroderma, Systemic / complications Vascular Diseases / etiology
Immunosuppressants Systemic sclerosis Targeted therapy Treatments

Journal

Presse medicale (Paris, France : 1983)
ISSN: 2213-0276
Titre abrégé: Presse Med
Pays: France
ID NLM: 8302490

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 14 10 2021
accepted: 20 10 2021
pubmed: 1 11 2021
medline: 30 12 2021
entrez: 31 10 2021
Statut: ppublish

Résumé

Systemic sclerosis (SSc) is a rare connective tissue disease characterized by skin and visceral fibrosis, vascular hyperreactivity and obliterative vasculopathy. Some of its complications such as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH) and heart involvement can be life-threatening and are associated with a high mortality and a poor prognosis. Many clinical trials were carried out in order to improve the survival and prognosis of SSc patients. The management of SSc is based on the frequent and regular assessment of the potential organ damage, and if present, the establishment of graduated pharmacological therapeutic strategies, associated with non-pharmacological procedures. Several randomized clinical trials have showed significant positive outcomes regarding some specific involvements. Many advances have been made, especially in the field of targeted therapies and personalized medicine, based on specific characteristics of the patient and the SSc.

Identifiants

DOI: 10.1016/j.lpm.2021.104088 PMID: 34718109
pubmed: 34718109
pii: S0755-4982(21)00027-0
doi: 10.1016/j.lpm.2021.104088
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104088

Informations de copyright

Copyright © 2021. Published by Elsevier Masson SAS.

Auteurs

Benjamin Thoreau (B)

Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris; Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Benjamin Chaigne (B)

Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris; Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

Arthur Renaud (A)

Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris; Service de Médecine Interne, Centre de Compétence Maladies Systémiques Autoimmunes Rares, CHU de Nantes, Nantes, France.

Luc Mouthon (L)

Institut Cochin, INSERM U1016, CNRS UMR 8104, Université de Paris; Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes Rares d'Ile de France, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France. Electronic address: luc.mouthon@aphp.fr.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Treatment of systemic sclerosis.
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation cellulaire › Transplantation de cellules souches › Transplantation de cellules souches hématopoïétiques › Treatment of systemic sclerosis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treatment of systemic sclerosis.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Treatment of systemic sclerosis.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Treatment of systemic sclerosis.
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Treatment of systemic sclerosis.
questionsmedicales.fr › Diagnostic › Pronostic › Treatment of systemic sclerosis.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Hypertension artérielle pulmonaire › Treatment of systemic sclerosis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Treatment of systemic sclerosis.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Sclérodermie systémique › Treatment of systemic sclerosis.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Treatment of systemic sclerosis.