Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria.
Animals
Antigens, Differentiation, B-Lymphocyte
/ chemistry
CD8-Positive T-Lymphocytes
/ immunology
Histocompatibility Antigens Class II
/ chemistry
Inflammation
/ etiology
Liver
/ immunology
Macrophage Migration-Inhibitory Factors
/ antagonists & inhibitors
Malaria, Cerebral
/ etiology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Plasmodium berghei
/ physiology
CD74
PMIF
apoptosis
cerebral malaria
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
23
09
2021
received:
01
07
2021
accepted:
04
10
2021
entrez:
1
11
2021
pubmed:
2
11
2021
medline:
21
12
2021
Statut:
ppublish
Résumé
The deadliest complication of infection by Plasmodium parasites, cerebral malaria, accounts for the majority of malarial fatalities. Although our understanding of the cellular and molecular mechanisms underlying the pathology remains incomplete, recent studies support the contribution of systemic and neuroinflammation as the cause of cerebral edema and blood-brain barrier (BBB) dysfunction. All Plasmodium species encode an orthologue of the innate cytokine, Macrophage Migration Inhibitory Factor (MIF), which functions in mammalian biology to regulate innate responses. Plasmodium MIF (PMIF) similarly signals through the host MIF receptor CD74, leading to an enhanced inflammatory response. We investigated the PMIF-CD74 interaction in the onset of experimental cerebral malaria (ECM) and liver stage Plasmodium development by using a combination of CD74 deficient (Cd74
Identifiants
pubmed: 34719814
doi: 10.1096/fj.202101072R
pmc: PMC9022605
mid: NIHMS1788970
doi:
Substances chimiques
Antigens, Differentiation, B-Lymphocyte
0
Histocompatibility Antigens Class II
0
Macrophage Migration-Inhibitory Factors
0
invariant chain
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21997Subventions
Organisme : NIAID NIH HHS
ID : R01 AI110452
Pays : United States
Informations de copyright
© 2021 Federation of American Societies for Experimental Biology.
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