Mapping Pulmonary and Systemic Inflammation in Preschool Aged Children With Cystic Fibrosis.
BAL
cystic fibrosis
flow cytometry
immune profiling
lung diseases
paediatrics
respiratory
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
30
06
2021
accepted:
29
09
2021
entrez:
1
11
2021
pubmed:
2
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
The immune landscape of the paediatric respiratory system remains largely uncharacterised and as a result, the mechanisms of globally important childhood respiratory diseases remain poorly understood. In this work, we used high parameter flow cytometry and inflammatory cytokine profiling to map the local [bronchoalveolar lavage (BAL)] and systemic (whole blood) immune response in preschool aged children with cystic fibrosis (CF) and aged-matched healthy controls. We demonstrate that children with CF show pulmonary infiltration of CD66b
Identifiants
pubmed: 34721395
doi: 10.3389/fimmu.2021.733217
pmc: PMC8554310
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
733217Informations de copyright
Copyright © 2021 Shanthikumar, Ranganathan, Saffery and Neeland.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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