Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.

Animals Carnitine / analogs & derivatives Ischemia Male Mice Mice, Knockout Mitochondria, Heart Reperfusion
Acylcarnitine Fatty acid metabolism Gamma-butyrobetaine Myocardial infarction PUFA Trimethyllysine

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
12 2021
Historique:
received: 19 08 2021
revised: 17 09 2021
accepted: 27 10 2021
pubmed: 4 11 2021
medline: 15 12 2021
entrez: 3 11 2021
Statut: ppublish

Résumé

Increased tissue content of long-chain acylcarnitines may induce mitochondrial and cardiac damage by stimulating ROS production. N

Identifiants

DOI: 10.1016/j.freeradbiomed.2021.10.035 PMID: 34728372
pubmed: 34728372
pii: S0891-5849(21)00785-1
doi: 10.1016/j.freeradbiomed.2021.10.035
pii:
doi:

Substances chimiques

acylcarnitine 0
Carnitine S7UI8SM58A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

370-380

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Edgars Liepinsh (E)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia. Electronic address: ledgars@farm.osi.lv.

Janis Kuka (J)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Karlis Vilks (K)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Baiba Svalbe (B)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Gundega Stelfa (G)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Reinis Vilskersts (R)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia; Riga Stradins University, Dzirciema Str 16, Riga, LV1007, Latvia.

Eduards Sevostjanovs (E)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Niks Ricards Goldins (NR)

Riga Stradins University, Dzirciema Str 16, Riga, LV1007, Latvia.

Valerija Groma (V)

Riga Stradins University, Dzirciema Str 16, Riga, LV1007, Latvia.

Solveiga Grinberga (S)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Mario Plaas (M)

Laboratory Animal Center, University of Tartu, Ravila 14b, Tartu, 50411, Estonia.

Marina Makrecka-Kuka (M)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia.

Maija Dambrova (M)

Latvian Institute of Organic Synthesis, Aizkraukles Str 21, Riga, LV1006, Latvia; Riga Stradins University, Dzirciema Str 16, Riga, LV1007, Latvia.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Low cardiac content of long-chain...
questionsmedicales.fr › Composés chimiques organiques › Amines › Composés de triméthyl-ammonium › Carnitine › Low cardiac content of long-chain...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Ischémie › Low cardiac content of long-chain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Low cardiac content of long-chain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Low cardiac content of long-chain...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondries du muscle › Mitochondries du myocarde › Low cardiac content of long-chain...
questionsmedicales.fr › Techniques d'investigation › Perfusion › Reperfusion › Low cardiac content of long-chain...