Applications of nanodosimetry in particle therapy planning and beyond.
DNA damage assays
Monte Carlo track structure simulations
nanodosimetry
particle therapy
radiation protection
treatment planning
Journal
Physics in medicine and biology
ISSN: 1361-6560
Titre abrégé: Phys Med Biol
Pays: England
ID NLM: 0401220
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
received:
22
06
2021
accepted:
03
11
2021
pubmed:
4
11
2021
medline:
5
4
2022
entrez:
3
11
2021
Statut:
epublish
Résumé
This topical review summarizes underlying concepts of nanodosimetry. It describes the development and current status of nanodosimetric detector technology. It also gives an overview of Monte Carlo track structure simulations that can provide nanodosimetric parameters for treatment planning of proton and ion therapy. Classical and modern radiobiological assays that can be used to demonstrate the relationship between the frequency and complexity of DNA lesion clusters and nanodosimetric parameters are reviewed. At the end of the review, existing approaches of treatment planning based on relative biological effectiveness (RBE) models or dose-averaged linear energy transfer are contrasted with an RBE-independent approach based on nandosimetric parameters. Beyond treatment planning, nanodosimetry is also expected to have applications and give new insights into radiation protection dosimetry.
Identifiants
pubmed: 34731854
doi: 10.1088/1361-6560/ac35f1
pmc: PMC8966218
mid: NIHMS1763601
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : P20 CA183640
Pays : United States
Informations de copyright
© 2021 Institute of Physics and Engineering in Medicine.
Références
EMBO J. 2010 Apr 21;29(8):1446-57
pubmed: 20360682
Annu Rev Biochem. 2010;79:181-211
pubmed: 20192759
Int J Radiat Oncol Biol Phys. 2016 Dec 1;96(5):1097-1106
pubmed: 27869082
Radiat Prot Dosimetry. 2004;110(1-4):789-99
pubmed: 15353748
Nat Rev Genet. 2006 Jan;7(1):45-54
pubmed: 16369571
Phys Med Biol. 2019 Jan 04;64(1):015015
pubmed: 30523890
Nucleic Acids Res. 2012 Jul;40(13):5965-74
pubmed: 22467212
Mol Cell. 2016 Sep 1;63(5):898-911
pubmed: 27477910
Int J Radiat Biol. 1997 May;71(5):467-83
pubmed: 9191891
Radiat Prot Dosimetry. 2018 Aug 1;180(1-4):177-181
pubmed: 29194515
Radiat Res. 2004 Oct;162(4):453-63
pubmed: 15447036
Nat Methods. 2013 Apr;10(4):361-5
pubmed: 23503052
PLoS One. 2013;8(2):e57953
pubmed: 23469115
PLoS One. 2012;7(5):e38165
pubmed: 22666473
Radiat Prot Dosimetry. 2002;99(1-4):77-80
pubmed: 12194365
J ICRU. 2011 Apr;11(1):1-31
pubmed: 24174259
Radiat Res. 2015 May;183(5):525-40
pubmed: 25909147
Int J Radiat Biol. 1994 Jan;65(1):7-17
pubmed: 7905912
Mutat Res. 2011 Jun 3;711(1-2):28-40
pubmed: 21281649
Mol Cell. 2008 Jul 25;31(2):167-77
pubmed: 18657500
Radiat Prot Dosimetry. 2014 Oct;161(1-4):464-8
pubmed: 24327751
Phys Med Biol. 2012 Feb 7;57(3):591-608
pubmed: 22222720
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Biochem Cell Biol. 2011 Feb;89(1):45-60
pubmed: 21326362
Med Phys. 2015 Aug;42(8):4840-7
pubmed: 26233211
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8293-8
pubmed: 21527720
Phys Med Biol. 2017 Dec 19;63(1):01TR02
pubmed: 28976361
Int J Radiat Biol. 1996 Nov;70(5):493-503
pubmed: 8947529
Radiat Res. 2011 Jun;175(6):797-805
pubmed: 21466384
EMBO J. 2011 Mar 16;30(6):1079-92
pubmed: 21317870
Int J Radiat Biol. 1994 Nov;66(5):427-32
pubmed: 7983426
DNA Repair (Amst). 2011 Apr 3;10(4):427-37
pubmed: 21342792
Radiat Prot Dosimetry. 2019 May 1;183(1-2):17-21
pubmed: 30535286
Mutat Res. 2003 Oct 29;531(1-2):93-107
pubmed: 14637248
Genes (Basel). 2019 Nov 16;10(11):
pubmed: 31744120
Med Phys. 2009 Jan;36(1):149-63
pubmed: 19235384
Sci Rep. 2015 May 18;5:9850
pubmed: 25984967
Biochem J. 2009 Feb 1;417(3):639-50
pubmed: 19133841
DNA Repair (Amst). 2010 Dec 10;9(12):1273-82
pubmed: 21036673
Radiat Res. 1996 Feb;145(2):200-9
pubmed: 8606930
Cell Cycle. 2010 Feb 15;9(4):662-9
pubmed: 20139725
Int J Radiat Biol. 1997 Apr;71(4):347-63
pubmed: 9154139
Radiat Prot Dosimetry. 2004;110(1-4):851-7
pubmed: 15353758
Int J Mol Sci. 2018 Feb 08;19(2):
pubmed: 29419809
Radiat Prot Dosimetry. 2002;99(1-4):331-5
pubmed: 12194317
Radiat Res. 1996 Oct;146(4):361-8
pubmed: 8927707
Radiat Prot Dosimetry. 2006;122(1-4):82-5
pubmed: 17251251
Med Phys. 2019 Feb;46(2):983-998
pubmed: 30536689
Bull Cancer Radiother. 1996;83 Suppl:50s-4s
pubmed: 8949752
Radiat Environ Biophys. 2002 Dec;41(4):235-56
pubmed: 12541070
Cancers (Basel). 2019 Nov 26;11(12):
pubmed: 31779276
Phys Med Biol. 2016 May 21;61(10):3698-711
pubmed: 27081911
Trends Biochem Sci. 2011 May;36(5):262-71
pubmed: 21353781
Sci Rep. 2017 Mar 27;7:45161
pubmed: 28345622
J Radiat Res. 2007;48 Suppl A:A81-6
pubmed: 17513903
Med Phys. 2018 Nov;45(11):e925-e952
pubmed: 30421808
Radiat Res. 2005 Jun;163(6):681-90
pubmed: 15913400
Radiat Prot Dosimetry. 2007;126(1-4):453-6
pubmed: 17562652
Phys Med Biol. 2010 Nov 21;55(22):6721-37
pubmed: 21030747
PLoS Genet. 2015 Aug 11;11(8):e1005438
pubmed: 26263206
Radiat Prot Dosimetry. 2011 Feb;143(2-4):455-8
pubmed: 21127036
Med Phys. 1998 Jul;25(7 Pt 1):1157-70
pubmed: 9682201
Nat Struct Mol Biol. 2017 Apr;24(4):353-361
pubmed: 28263325
Radiother Oncol. 2016 Aug;120(2):307-12
pubmed: 27394694
Int J Radiat Biol. 1992 May;61(5):611-24
pubmed: 1349625
Australas Phys Eng Sci Med. 2020 Jan 6;:
pubmed: 31909818
Phys Med. 2001;17 Suppl 1:177-80
pubmed: 11771551
Rep Pract Oncol Radiother. 2014 May 19;19(Suppl):S42-S46
pubmed: 28443198
Int J Radiat Oncol Biol Phys. 2020 Jul 1;107(3):571-578
pubmed: 32234554
Mutat Res. 2009 Jan-Feb;681(1):13-23
pubmed: 18083062
Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1177-83
pubmed: 20732758
Z Med Phys. 2015 Jun;25(2):168-75
pubmed: 25432332
Med Phys. 2019 Feb;46(2):1064-1074
pubmed: 30565705
Med Phys. 2018 Jun 14;:
pubmed: 29901835
J Radiat Res. 2008 Nov;49(6):645-52
pubmed: 18987440
Phys Med Biol. 2010 Feb 7;55(3):761-81
pubmed: 20071772
Nucleic Acids Res. 2011 Aug;39(15):6489-99
pubmed: 21511815
Radiat Res. 1994 Dec;140(3):366-74
pubmed: 7972689
Nat Rev Clin Oncol. 2017 Aug;14(8):483-495
pubmed: 28290489
Phys Med. 2015 Dec;31(8):861-874
pubmed: 26653251
Med Phys. 2012 Nov;39(11):6818-37
pubmed: 23127075
Phys Med Biol. 2014 Nov 21;59(22):R419-72
pubmed: 25361443
Radiat Environ Biophys. 2002 Jun;41(2):103-12
pubmed: 12201053
Nat Commun. 2019 May 24;10(1):2313
pubmed: 31127121
Acta Oncol. 2001;40(6):682-5
pubmed: 11765060
Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1559-66
pubmed: 21163588
Phys Med Biol. 2008 Mar 21;53(6):1689-700
pubmed: 18367797
Semin Radiat Oncol. 2018 Apr;28(2):88-96
pubmed: 29735195
Cancers (Basel). 2015 Feb 12;7(1):353-81
pubmed: 25686476
Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):650-6
pubmed: 16414376
Nucleus. 2010 Mar-Apr;1(2):166-78
pubmed: 21326949
Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506
pubmed: 28512351
Cancer Res. 1991 Sep 1;51(17):4671-6
pubmed: 1873812
J Phys Chem B. 2005 Sep 8;109(35):16967-73
pubmed: 16853159
Methods Cell Biol. 2004;75:355-73
pubmed: 15603433
Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3172-7
pubmed: 19221031
BMC Genomics. 2017 Jul 7;18(1):519
pubmed: 28687070
Radiat Prot Dosimetry. 2004;110(1-4):845-50
pubmed: 15353757
Radiat Prot Dosimetry. 2014 Oct;161(1-4):445-8
pubmed: 24249779
J Vis Exp. 2012 Sep 28;(67):
pubmed: 23052275
Phys Med Biol. 2013 May 21;58(10):3089-105
pubmed: 23594445
Radiat Res. 2001 Nov;156(5 Pt 2):577-83
pubmed: 11604075
Radiat Environ Biophys. 2015 Aug;54(3):343-52
pubmed: 26007308
Cold Spring Harb Perspect Med. 2015 Sep 18;5(10):
pubmed: 26385091
Radiat Res. 1990 Feb;121(2):196-205
pubmed: 2305038
Mol Cell Biol. 2005 Feb;25(3):896-906
pubmed: 15657419
Lancet Oncol. 2015 Feb;16(2):e93-e100
pubmed: 25638685
Phys Med Biol. 2018 May 04;63(9):095011
pubmed: 29726401
Phys Med Biol. 2017 Jul 06;62(15):5908-5925
pubmed: 28594336
Med Phys. 2014 Dec;41(12):121708
pubmed: 25471955
Int J Radiat Biol. 2018 Aug;94(8):759-768
pubmed: 29219655
Phys Med Biol. 2015 Apr 21;60(8):3271-86
pubmed: 25826534
Med Phys. 2010 Sep;37(9):4692-708
pubmed: 20964188
Radiat Res. 2002 Oct;158(4):486-92
pubmed: 12236816
Med Phys. 2019 Mar;46(3):1501-1511
pubmed: 30689203
Int J Mol Sci. 2018 Nov 22;19(12):
pubmed: 30469529
Radiat Environ Biophys. 2002 Jun;41(2):91-102
pubmed: 12201061
Radiother Oncol. 2016 Oct;121(1):154-161
pubmed: 27637859
Radiat Res. 1998 Aug;150(2):170-82
pubmed: 9692362
Z Med Phys. 2008;18(4):286-96
pubmed: 19205298
Radiat Prot Dosimetry. 2015 Sep;166(1-4):223-7
pubmed: 25877534
Nucleic Acids Res. 2004 Mar 05;32(4):1602-9
pubmed: 15004247
J Phys Chem B. 2017 Jan 26;121(3):497-507
pubmed: 28045263
Int J Radiat Biol. 2003 May;79(5):351-8
pubmed: 12943243
Br J Radiol. 2015 Jan;88(1045):20140392
pubmed: 25257709
Environ Mol Mutagen. 2015 Jul;56(6):491-504
pubmed: 25773265
Nature. 2000 Nov 23;408(6811):433-9
pubmed: 11100718
Br J Cancer. 2019 Apr;120(8):777-778
pubmed: 30531831
Med Phys. 2018 Nov;45(11):e1096-e1110
pubmed: 30421806
Med Phys. 2014 Aug;41(8):081701
pubmed: 25086511
J Theor Biol. 1987 Jul 21;127(2):229-45
pubmed: 2826926
Radiat Environ Biophys. 2015 May;54(2):167-74
pubmed: 25616548
Health Phys. 2012 Nov;103(5):590-5
pubmed: 23032889
Radiat Prot Dosimetry. 2006;122(1-4):415-9
pubmed: 17283009
Radiat Res. 2019 Jan;191(1):76-92
pubmed: 30407901
Radiother Oncol. 2018 Dec;129(3):600-610
pubmed: 30049456
Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):70-77
pubmed: 27084630
Radiat Oncol. 2015 Feb 18;10:42
pubmed: 25880907
Int J Mol Sci. 2012;13(9):11844-60
pubmed: 23109886
Acta Oncol. 2019 Oct;58(10):1536-1539
pubmed: 31303083
Phys Med Biol. 2018 Nov 09;63(22):225009
pubmed: 30412471
Radiat Environ Biophys. 1997 Feb;36(1):59-66
pubmed: 9128899
J Biol Chem. 2018 Jul 6;293(27):10524-10535
pubmed: 29599286
Cold Spring Harb Perspect Biol. 2013 May 01;5(5):a012757
pubmed: 23637284
Radiat Environ Biophys. 2011 Aug;50(3):345-52
pubmed: 21559952
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1136-43
pubmed: 21075549
Radiat Environ Biophys. 2021 Nov;60(4):559-578
pubmed: 34427743
Science. 2007 May 25;316(5828):1153-8
pubmed: 17525330
Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):216-22
pubmed: 23790771
Cell. 1984 May;37(1):67-75
pubmed: 6373014
Radiat Prot Dosimetry. 2015 Sep;166(1-4):253-6
pubmed: 25897141
Exp Cell Res. 1988 Mar;175(1):184-91
pubmed: 3345800
Radiat Res. 2013 Jan;179(1):21-8
pubmed: 23148508
Yeast. 1987 Jun;3(2):71-6
pubmed: 3332967
Mutat Res. 2013 Oct;750(1-2):5-14
pubmed: 23916969
Phys Med Biol. 2017 Sep 12;62(19):7569-7597
pubmed: 28895552
Nat Protoc. 2006;1(1):23-9
pubmed: 17406208
Int J Radiat Biol. 1992 Jun;61(6):737-48
pubmed: 1351522
Radiat Res. 1993 Feb;133(2):158-62
pubmed: 8382369
Radiat Res. 2019 Feb;191(2):125-138
pubmed: 30609382
Med Phys. 2020 Nov;47(11):5872-5881
pubmed: 32285455
Radiat Res. 1993 Nov;136(2):190-6
pubmed: 8248475
PLoS Genet. 2013;9(8):e1003667
pubmed: 23935532
Radiat Res. 1991 May;126(2):251-9
pubmed: 1850853
Genes (Basel). 2019 Jan 04;10(1):
pubmed: 30621219
Biochem Biophys Res Commun. 1984 Aug 30;123(1):291-8
pubmed: 6477583
Nat Methods. 2016 Oct;13(10):855-7
pubmed: 27525976
Phys Med Biol. 2020 Apr 23;65(8):085015
pubmed: 32101803
Radiat Res. 1993 Jul;135(1):16-23
pubmed: 8392212
Phys Med Biol. 2018 Sep 06;63(17):175018
pubmed: 30088810
Radiat Res. 2003 Mar;159(3):401-10
pubmed: 12600243
Nat Commun. 2017 May 12;8:15058
pubmed: 28497783
Med Phys. 2018 Nov;45(11):e1011-e1023
pubmed: 30421811
Methods Enzymol. 2006;409:236-50
pubmed: 16793405
Radiat Res. 2008 Apr;169(4):437-46
pubmed: 18363429
Phys Med Biol. 2012 Nov 21;57(22):7543-54
pubmed: 23104051
EMBO J. 2008 Feb 20;27(4):589-605
pubmed: 18285820
Radiat Prot Dosimetry. 2015 Sep;166(1-4):339-42
pubmed: 25953788
Acta Oncol. 2013 Apr;52(3):589-603
pubmed: 23409790
Nat Rev Mol Cell Biol. 2014 Jan;15(1):7-18
pubmed: 24326623
Radiat Prot Dosimetry. 2018 Aug 1;180(1-4):182-186
pubmed: 29474694
Radiat Res. 1990 Apr;122(1):86-94
pubmed: 2320728
Radiat Res. 2008 Aug;170(2):156-62
pubmed: 18666814
Phys Med Biol. 2021 Mar 04;66(6):06NT02
pubmed: 33588391
J Phys Chem A. 2006 May 11;110(18):6112-21
pubmed: 16671682
Nat Struct Mol Biol. 2010 Mar;17(3):299-305
pubmed: 20139982
Mol Cell Biol. 2014 Apr;34(8):1380-8
pubmed: 24469398
Med Phys. 2020 Feb;47(2):772-780
pubmed: 31705768
Int J Radiat Biol. 1991 Mar;59(3):677-97
pubmed: 1672357
Radiat Res. 2015 Feb;183(2):174-87
pubmed: 25587741
Radiat Environ Biophys. 1999 May;38(1):31-8
pubmed: 10384953
Mutat Res. 2010 Apr-Jun;704(1-3):88-100
pubmed: 20144732
Commun Biol. 2018 Oct 31;1:181
pubmed: 30393778
Methods Mol Biol. 2016;1373:117-30
pubmed: 25682374
Radiother Oncol. 2021 Oct;163:143-149
pubmed: 34461183
Prog Nucleic Acid Res Mol Biol. 1988;35:95-125
pubmed: 3065826
Nat Commun. 2017 Jan 16;8:14049
pubmed: 28091601
J Vis Exp. 2017 Oct 11;(128):
pubmed: 29053680
Mol Cell. 2004 Dec 3;16(5):715-24
pubmed: 15574327
Radiat Prot Dosimetry. 2006;122(1-4):28-31
pubmed: 17251255
Radiat Prot Dosimetry. 2018 Aug 1;180(1-4):150-156
pubmed: 29036364
Trends Biochem Sci. 2017 Sep;42(9):690-701
pubmed: 28739276
Methods. 2009 May;48(1):63-71
pubmed: 19245833
Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):201-10
pubmed: 10219815
Int J Radiat Oncol Biol Phys. 2020 Nov 1;108(3):779-791
pubmed: 32504659
Genome Res. 2013 Apr;23(4):705-15
pubmed: 23249883
Mol Cell. 2014 Jan 9;53(1):7-18
pubmed: 24316220
Cell. 2015 May 21;161(5):1187-1201
pubmed: 26000487
Comput Math Methods Med. 2015;2015:908971
pubmed: 26167202
J Biol Chem. 1998 Mar 6;273(10):5858-68
pubmed: 9488723
Int J Radiat Biol. 2005 Jan;81(1):41-54
pubmed: 15962762
Cancers (Basel). 2020 Mar 26;12(4):
pubmed: 32225023
Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):109-119
pubmed: 32911019
Phys Med Biol. 2018 Nov 28;63(23):235015
pubmed: 30484432
Sci Rep. 2020 Nov 27;10(1):20788
pubmed: 33247225
J Cell Biol. 1999 Sep 6;146(5):905-16
pubmed: 10477747
Br J Radiol. 2020 Mar;93(1107):20190334
pubmed: 31738081
Nat Protoc. 2016 May;11(5):853-71
pubmed: 27031497
Phys Med Biol. 2015 Oct 21;60(20):7805-28
pubmed: 26406277
Phys Med. 2016 Oct;32(10):1187-1200
pubmed: 27659007
Phys Chem Chem Phys. 2017 Aug 2;19(30):20016-20028
pubmed: 28722734
Radiat Res Suppl. 1985;8:S103-11
pubmed: 3867077
Int J Radiat Biol. 1998 Aug;74(2):173-84
pubmed: 9712547
DNA Repair (Amst). 2005 Sep 28;4(10):1129-39
pubmed: 15994132
Int J Mol Sci. 2020 Sep 09;21(18):
pubmed: 32917044
Br J Radiol. 2020 Nov 1;93(1115):20191054
pubmed: 32105514
DNA Repair (Amst). 2015 Apr;28:93-106
pubmed: 25659339